Kennedy-Nasser Alana A, Hanley Patrick, Bollard Catherine M
Baylor College of Medicine, Texas Children's Hospital, TX, USA.
Pediatr Hematol Oncol. 2011 Apr;28(3):176-86. doi: 10.3109/08880018.2011.557261.
Hodgkin disease (HD) is a malignancy of primarily B lymphocytes that has the unique ability to cause immunodeficiency, as well as provide immune evasion mechanisms to avoid self-destruction. In this review, the authors discuss Hodgkin disease, its association with Epstein-Barr virus (EBV), the immune deficiency caused by HD, and tumor immune evasion mechanisms. Specifically, the authors closely evaluate the roles of regulatory T cells in HD, cytotoxic T cells, cytokine and chemokine secretion, down-regulation of Fas ligand, and indoleamine 2,3-dioxygenase (IDO) secretion.
霍奇金淋巴瘤（HD）是一种主要起源于B淋巴细胞的恶性肿瘤，具有导致免疫缺陷的独特能力，同时还具备免疫逃逸机制以避免自身毁灭。在本综述中，作者讨论了霍奇金淋巴瘤、其与爱泼斯坦-巴尔病毒（EBV）的关联、HD所致的免疫缺陷以及肿瘤免疫逃逸机制。具体而言，作者深入评估了调节性T细胞、细胞毒性T细胞、细胞因子和趋化因子分泌、Fas配体下调以及吲哚胺2,3-双加氧酶（IDO）分泌在HD中的作用。
