Bhat Vishwanath, Karam Michelle, Saslow Judy, Taylor Heidi, Pyon Kee, Kemble Nicole, Stahl Gary, Goodman Michael, Aghai Zubair H
Department of Pediatrics/Neonatology, Cooper University Hospital-Robert Wood Johnson Medical School, One Cooper Plaza, Camden, NJ 08103, USA.
J Matern Fetal Neonatal Med. 2012 Feb;25(2):116-9. doi: 10.3109/14767058.2011.557755. Epub 2011 Mar 7.
The American Academy of Neurology and Child Neurology Society recommend performing routine screening head ultrasounds (HUS) on preterm infants of less than 30 weeks gestation.
To study the incidence of intraventricular hemorrhage (IVH) and evaluate the need for screening HUS in preterm infants with gestational age (GA) of 30-34 weeks.
DESIGN/METHODS: Preterm infants (GA; 30-34 weeks) admitted to the neonatal intensive care unit (NICU) between January 1997 and September 2007 were included in this study. Grades of IVH were defined as per the Papile classification.
Screening HUS were performed on 463 infants with GA of 30-34 weeks. Twenty-seven (5.8%) infants had abnormal cranial ultrasound (US) (IVH or periventricular leucomalacia [PVL]). The incidence of IVH ranged from 3.3% to 6.3% at various GA. Seven (1.5%) infants had severe abnormalities on HUS (grades III/IV or PVL).
A significant number of infants born between 30 and 34 weeks of gestation have abnormalities on screening cranial US. Since not all infants born at 30-34 weeks of gestation received a HUS, the incidence of HUS abnormalities might have been overestimated due to a possible 'selection bias'. Additional studies are needed to examine the adverse neurodevelopmental outcomes in this group of preterm infants with mild abnormalities (IVH grades I or II) on cranial US before recommending routine screenings for IVH.
美国神经病学学会和儿童神经病学学会建议对孕周小于30周的早产儿进行常规头颅超声(HUS)筛查。
研究脑室内出血(IVH)的发生率,并评估对孕周为30 - 34周的早产儿进行HUS筛查的必要性。
设计/方法:纳入1997年1月至2007年9月期间入住新生儿重症监护病房(NICU)的孕周为30 - 34周的早产儿。IVH分级按照Papile分类法确定。
对463例孕周为30 - 34周的婴儿进行了HUS筛查。27例(5.8%)婴儿头颅超声(US)异常(IVH或脑室周围白质软化[PVL])。不同孕周时IVH的发生率在3.3%至6.3%之间。7例(1.5%)婴儿HUS有严重异常(III/IV级或PVL)。
相当数量的孕周在30至34周之间出生的婴儿在头颅US筛查时有异常。由于并非所有孕周为30 - 34周的婴儿都接受了HUS检查,可能存在“选择偏倚”,HUS异常的发生率可能被高估。在建议对IVH进行常规筛查之前,需要进一步研究来检查这组头颅US有轻度异常(IVH I级或II级)的早产儿的不良神经发育结局。