Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Enzyme Inhib Med Chem. 2011 Dec;26(6):805-12. doi: 10.3109/14756366.2011.555944. Epub 2011 Mar 7.
Some fused dihydrooxepino[f]-, [g]-, and [h]coumarins were obtained from the ring-closing metathesis of the corresponding o-allyl-allyloxycoumarins under the treatment with the first generation Grubbs' catalyst. These compounds were tested in vitro for their antioxidant activity, and they present significant scavenging activity. They were also showed to inhibit in vitro soybean lipoxygenase.
一些融合的二氢氧杂环庚[f]、[g]和[h]香豆素是通过相应的邻烯丙基-烯丙氧基香豆素在第一代 Grubbs 催化剂作用下的闭环复分解反应得到的。这些化合物在体外进行了抗氧化活性测试，表现出显著的清除活性。它们还被证明可以抑制体外大豆脂氧合酶。
