Zaraa I, Mlika M, Chouk S, Chelly I, Mokni M, Zitouna M, Osman A Ben
Department of Dermatology, La Rabta Hospital, Tunis, Tunisia.
Dermatol Online J. 2011 Feb 15;17(2):1.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vasoproliferative disease of undetermined origin. It is characterized by the presence of nodular pseudo-tumors corresponding microscopically to a vascular proliferation within an inflammatory infiltrate made up of lymphocytes, macrophages, and eosinophils. The authors describe 7 cases of ALHE.
The 7 cases were diagnosed over a period of 19 years (1990-2008). Clinical data and histological slides were brought from the departments of dermatology and pathology of the Rabta Hospital.
The 7 patients were 4 women and 3 men with an average age of 34.5 years. The cephalic localization was the most frequent. Lesions were solitary or multiple and formed papules or plaques of variable color. The diagnosis was based in all cases on histological findings.
The main disease in the differential diagnosis of ALHE is Kimura disease, but the 2 entities have several clinical and histological differences. The pathogenesis remains unclear and there is no consensus on the best treatment.
嗜酸性粒细胞增多性血管淋巴样增生（ALHE）是一种起源不明的良性血管增生性疾病。其特征是存在结节状假肿瘤，在显微镜下对应于由淋巴细胞、巨噬细胞和嗜酸性粒细胞组成的炎症浸润内的血管增生。作者描述了7例ALHE病例。
这7例病例在19年（1990 - 2008年）期间被诊断出来。临床资料和组织学切片来自拉卜塔医院皮肤科和病理科。
7例患者中4例为女性，3例为男性，平均年龄34.5岁。头部是最常见的发病部位。病变为单发或多发，形成颜色各异的丘疹或斑块。所有病例的诊断均基于组织学检查结果。
ALHE鉴别诊断中的主要疾病是木村病，但这两种疾病在临床和组织学上有若干差异。其发病机制仍不清楚，对于最佳治疗方法也没有共识。
