血清分泌型磷脂酶 A2 与腹主动脉瘤的存在有关，但与进展无关。
Serum secreted phospholipase A2 is associated with abdominal aortic aneurysm presence but not progression.
机构信息
Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Townsville 4811, Australia.
出版信息
Atherosclerosis. 2011 Jun;216(2):458-60. doi: 10.1016/j.atherosclerosis.2011.02.022. Epub 2011 Feb 18.
OBJECTIVE
Secretory phospholipase A(2) (sPLA(2)) has been implicated in rodent models of abdominal aortic aneurysm (AAA). The aim of this study was to assess whether serum sPLA(2) activity was associated with AAA presence and progression.
METHODS
Serum sPLA(2) activity was measured using a fluorometric assay in 1002 men of whom 310 had an AAA. 272 of the men had repeat ultrasound surveillance of their AAA for a median of 5.5 years. The association of sPLA(2) activity with AAA was assessed using multiple regression analysis to adjust for other risk factors.
RESULTS
Median serum sPLA(2) activity was 21.67 in men with AAA and 18.32 U/ml in men without AAA, p<0.001. Men with sPLA(2) activity ≥ median (19.20 U/ml) had a 1.40-fold (95% CI 1.04-1.87, p=0.027) increased prevalence of AAA independent of other risk factors. Serum sPLA(2) activity was not associated with AAA growth.
CONCLUSION
Serum sPLA(2) activity is elevated in men with small AAAs but is not associated with AAA progression.
目的
分泌型磷脂酶 A2（sPLA2）与鼠类腹主动脉瘤（AAA）模型有关。本研究旨在评估血清 sPLA2 活性是否与 AAA 的存在和进展有关。
方法
采用荧光法测定 1002 名男性的血清 sPLA2 活性，其中 310 名男性患有 AAA。272 名男性对其 AAA 进行了中位数为 5.5 年的重复超声监测。使用多元回归分析来调整其他危险因素，评估 sPLA2 活性与 AAA 的相关性。
结果
AAA 男性的血清 sPLA2 活性中位数为 21.67 U/ml，无 AAA 男性为 18.32 U/ml，p<0.001。sPLA2 活性≥中位数（19.20 U/ml）的男性 AAA 患病率增加 1.40 倍（95%CI 1.04-1.87，p=0.027），独立于其他危险因素。血清 sPLA2 活性与 AAA 生长无关。
结论
血清 sPLA2 活性在小 AAA 男性中升高，但与 AAA 进展无关。
Zotero 插件