腹主动脉瘤疾病的新型生物标志物：识别差距并消除误解。
Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions.
作者信息
Moris Demetrios, Mantonakis Eleftherios, Avgerinos Efthymios, Makris Marinos, Bakoyiannis Chris, Pikoulis Emmanuel, Georgopoulos Sotirios
机构信息
First Department of Surgery, Vascular Unit, "Laiko" General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527 Athens, Greece.
Division of Vascular Surgery, University of Pittsburgh, Pittsburgh, PA 15213-2582, USA.
出版信息
Biomed Res Int. 2014;2014:925840. doi: 10.1155/2014/925840. Epub 2014 May 20.
Abstract
Abdominal aortic aneurysm (AAA) is a prevalent and potentially life-threatening disease. Early detection by screening programs and subsequent surveillance has been shown to be effective at reducing the risk of mortality due to aneurysm rupture. The aim of this review is to summarize the developments in the literature concerning the latest biomarkers (from 2008 to date) and their potential screening and therapeutic values. Our search included human studies in English and found numerous novel biomarkers under research, which were categorized in 6 groups. Most of these studies are either experimental or hampered by their low numbers of patients. We concluded that currently no specific laboratory markers allow screeing for the disease and monitoring its progression or the results of treatment. Further studies and studies in larger patient groups are required in order to validate biomarkers as cost-effective tools in the AAA disease.
摘要
腹主动脉瘤（AAA）是一种常见且可能危及生命的疾病。筛查计划进行的早期检测以及后续监测已被证明在降低因动脉瘤破裂导致的死亡风险方面是有效的。本综述的目的是总结文献中有关最新生物标志物（从2008年至今）及其潜在筛查和治疗价值的进展。我们的检索纳入了英文的人体研究，发现了众多正在研究的新型生物标志物，这些生物标志物被分为6组。这些研究大多是实验性的，或者因患者数量少而受到限制。我们得出结论，目前尚无特定的实验室标志物可用于该疾病的筛查、监测其进展或治疗结果。需要进一步开展研究以及在更大患者群体中进行研究，以便将生物标志物验证为腹主动脉瘤疾病中具有成本效益的工具。
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