合成在 C-4 位置用 N-磺酰亚氨基酰胺基团修饰的 2-脱氧-2,3-二去氢-N-乙酰神经氨酸类似物，并作为人副流感病毒 1 抑制剂的生物学评价。
Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1.
机构信息
Department of Organic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
出版信息
Bioorg Med Chem. 2011 Apr 1;19(7):2418-27. doi: 10.1016/j.bmc.2011.02.010. Epub 2011 Feb 18.
PMID:21382718
Abstract
Eleven novel sialidase inhibitors 9 and 10 with an N-sulfonylamidino group at the C-4 position of Neu5Ac2en 1 against human parainfluenza virus type 1 (hPIV-1) were synthesized using copper-catalyzed three-component coupling reactions, and their inhibitory activities against hPIV-1 sialidase were studied.
摘要
合成了 11 种新型唾液酸酶抑制剂 9 和 10，它们在 Neu5Ac2en 1 的 C-4 位置具有 N-磺酰亚氨基基团，用于抗人副流感病毒 1（hPIV-1），并使用铜催化的三组分偶联反应进行了研究。它们对 hPIV-1 唾液酸酶的抑制活性。
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