Garnier P, Nahoul K, Grenier J, Raynaud F, Job J C
Fondation de Recherche en Hormonologie, Fresnes, France.
Pathol Biol (Paris). 1990 Feb;38(2):105-12.
Somatomedin C/IGF I, dehydroepiandrosterone sulfate (DHAS), testosterone (T) or estradiol (E2) have been measured in 154 patients of a previous study in which growth hormone (GH) responses to classical pharmacologic stimuli and spontaneous growth hormone secretion during sleep were compared in short children before and at the beginning of puberty. Five groups were identified: Group I, normal growth hormone secreting children; group II, completely growth hormone deficient; group III, partially growth hormone deficient; group IV, with normal sleep secretion and low responses to stimuli; group V, with the reverse situation. The somatomedin C/IGF I levels were widely dispersed. In group I, the mean +/- SEM levels of somatomedin C/IGF I were 0.77 +/- 0.047 U/ml before puberty and 1.36 +/- 0.142 U/ml in early pubertal patients, with a relation to age (r = 0.52, p less than 0.001). The difference between prepubertal and pubertal patients was significant. In groups II to V, there was no pubertal rise of somatomedin C/IGF I. In group II, the mean IGF I level was 0.48 +/- 0.05 U/ml, significantly lower than in prepubertal patients of group I. In groups III, IV and V, it was 0.7 +/- 0.069 U/ml, 0.8 +/- 0.059 U/ml, and 0.73 +/- 0.059 U/ml respectively, not different from prepubertal patients of group I, but significantly lower than in early pubertal patients of the same group. In prepubertal patients, somatomedin C/IGFI was slightly but highly significantly correlated to the growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated together.(ABSTRACT TRUNCATED AT 250 WORDS)
在之前一项研究的154名患者中检测了生长调节素C/胰岛素样生长因子I（Somatomedin C/IGF I）、硫酸脱氢表雄酮（DHAS）、睾酮（T）或雌二醇（E2）。该研究比较了青春期前和青春期开始时矮小儿童对经典药理刺激的生长激素（GH）反应以及睡眠期间的自发性生长激素分泌。确定了五组：第一组，生长激素分泌正常的儿童；第二组，完全生长激素缺乏；第三组，部分生长激素缺乏；第四组，睡眠分泌正常但对刺激反应低；第五组，情况相反。生长调节素C/IGF I水平分布广泛。在第一组中，青春期前生长调节素C/IGF I的平均±标准误水平为0.77±0.047 U/ml，青春期早期患者为1.36±0.142 U/ml，与年龄相关（r = 0.52，p<0.001）。青春期前和青春期患者之间的差异显著。在第二组至第五组中，生长调节素C/IGF I没有青春期升高。在第二组中，IGF I平均水平为0.48±0.05 U/ml，显著低于第一组青春期前患者。在第三组、第四组和第五组中，分别为0.7±0.069 U/ml、0.8±0.059 U/ml和0.73±0.059 U/ml，与第一组青春期前患者无差异，但显著低于同一组青春期早期患者。在青春期前患者中，生长调节素C/IGFI与生长激素睡眠分泌（r = 0.27，p<0.001）和硫酸脱氢表雄酮（r = 0.36，p<0.001）轻度但高度显著相关，但生长激素和硫酸脱氢表雄酮之间不相关。（摘要截断于250字）
