Groupe Imagerie et Modélisation, Département Biologie Cellulaire et Infection, Institut Pasteur, F-75015 Paris, France.
J Cell Biol. 2011 Mar 7;192(5):723-33. doi: 10.1083/jcb.201010058.
The spatial organization of genes and chromosomes plays an important role in the regulation of several DNA processes. However, the principles and forces underlying this nonrandom organization are mostly unknown. Despite its small dimension, and thanks to new imaging and biochemical techniques, studies of the budding yeast nucleus have led to significant insights into chromosome arrangement and dynamics. The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order.
基因和染色体的空间组织在几个 DNA 过程的调控中起着重要作用。然而，这种非随机组织的原则和力大多是未知的。尽管酵母细胞核体积小，但由于新的成像和生化技术，对其进行的研究使得人们对染色体的排列和动态有了重大的认识。在有丝分裂间期，酵母基因组的动态组织支持染色质纤维的物理性质和特定分子相互作用作为核有序性的驱动力。
