Svensson T H, Usdin T
Science. 1978 Dec 8;202(4372):1089-91. doi: 10.1126/science.213833.
The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.
使用不同的受体阻断剂和单单位记录技术表明，三环类抗抑郁药对脑去甲肾上腺素能神经元的反馈抑制是由突触前α受体介导的。慢性丙咪嗪治疗后，大鼠脑海马蓝斑中的去甲肾上腺素能神经元仍部分受到抑制，这与临床数据一致。然而，它们对丙咪嗪或可乐定的进一步抑制具有抗性。
