Haraguchi M, Samson H H, Tolliver G A
Alcohol and Drug Abuse Institute, University of Washington, Seattle 98105.
Pharmacol Biochem Behav. 1990 Jan;35(1):259-62. doi: 10.1016/0091-3057(90)90236-b.
Long-Evans rats (N = 4) maintained on ad lib food and water were initiated to self-administer ethanol using the sucrose-substitution procedure. Following initiation, the rats received IP injections of fluoxetine HCl in sterile water 30 minutes before selected daily self-administration sessions. On other sessions, the rats were injected with sterile water only. Doses of 1, 2, 3, and 5 mg/kg were tested in a random order. Only one drug dose was given each week and each dose was tested at least twice except the 5 mg/kg dose. As dose increased, responding for ethanol decreased with significant reductions at both the 3 and 5 mg/kg dose. The nature of the decrease was such that the duration of continuous responding at the beginning of the session was reduced respective to control and noninjection performance. Overall, the findings of this study support prior work with fluoxetine and other 5-HT blockers which appear to affect satiety mechanisms and possibly reinforcement efficacy.
自由摄取食物和水的Long-Evans大鼠（N = 4）采用蔗糖替代程序开始自我给药乙醇。诱导期过后，在选定的每日自我给药时段前30分钟，给大鼠腹腔注射盐酸氟西汀的无菌水溶液。在其他时段，大鼠仅注射无菌水。以随机顺序测试1、2、3和5 mg/kg的剂量。每周仅给予一种药物剂量，除5 mg/kg剂量外，每种剂量至少测试两次。随着剂量增加，对乙醇的反应减少，在3和5 mg/kg剂量时均有显著降低。减少的性质是，与对照和未注射时的表现相比，时段开始时连续反应的持续时间缩短。总体而言，本研究结果支持先前关于氟西汀和其他5-羟色胺阻滞剂的研究，这些药物似乎会影响饱腹感机制以及可能的强化效果。
