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Metabolism unhinged: IDH mutations in cancer.

作者信息

Prensner John R, Chinnaiyan Arul M

出版信息

Nat Med. 2011 Mar;17(3):291-3. doi: 10.1038/nm0311-291.

DOI:10.1038/nm0311-291
PMID:21383741
Abstract
摘要

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Metabolism unhinged: IDH mutations in cancer.代谢紊乱：癌症中的异柠檬酸脱氢酶（IDH）突变
Nat Med. 2011 Mar;17(3):291-3. doi: 10.1038/nm0311-291.
2
Isocitrate dehydrogenase mutations in leukemia.白血病中异柠檬酸脱氢酶突变。
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3
Role of isocitrate dehydrogenase in glioma.异柠檬酸脱氢酶在脑胶质瘤中的作用。
Expert Rev Neurother. 2011 Oct;11(10):1399-409. doi: 10.1586/ern.11.134.
4
O-methylguanine-DNA methyltransferase promoter methylation and isocitrate dehydrogenase mutation as prognostic factors in a cohort of Saudi patients with glioblastoma.O-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化和异柠檬酸脱氢酶突变作为沙特胶质母细胞瘤患者队列中的预后因素。
Ann Saudi Med. 2019 Nov-Dec;39(6):410-416. doi: 10.5144/0256-4947.2019.410. Epub 2019 Dec 5.
5
Mutant metabolic enzymes are at the origin of gliomas.突变代谢酶是神经胶质瘤的起源。
Cancer Res. 2009 Dec 15;69(24):9157-9. doi: 10.1158/0008-5472.CAN-09-2650.
6
Differentiating between glioblastomas with and without isocitrate dehydrogenase gene mutation by findings on conventional magnetic resonance images.通过常规磁共振成像表现鉴别伴有和不伴有异柠檬酸脱氢酶基因突变的胶质母细胞瘤。
J Clin Neurosci. 2020 Jun;76:140-144. doi: 10.1016/j.jocn.2020.04.016. Epub 2020 Apr 11.
7
Clinical prognostic value of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in glioblastoma.IDH1 单核苷酸多态性 rs11554137 在胶质母细胞瘤中的临床预后价值。
J Neurooncol. 2018 Jun;138(2):307-313. doi: 10.1007/s11060-018-2796-6. Epub 2018 Feb 8.
8
Survival in patients with glioblastoma at a first progression does not correlate with isocitrate dehydrogenase (IDH)1 gene mutation status.初诊进展期胶质母细胞瘤患者的生存与异柠檬酸脱氢酶 1 基因（IDH1）突变状态无关。
Jpn J Clin Oncol. 2021 Jan 1;51(1):45-53. doi: 10.1093/jjco/hyaa162.
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Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.异柠檬酸脱氢酶状态与胶质瘤和胶质母细胞瘤的分子亚类
Neurosurg Focus. 2014 Dec;37(6):E13. doi: 10.3171/2014.9.FOCUS14505.
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Isocitrate dehydrogenase mutations in defining the biology of and supporting clinical decision making in glioblastoma.异柠檬酸脱氢酶突变在胶质母细胞瘤生物学特性的界定及临床决策支持中的作用
Ideggyogy Sz. 2018 Jul 30;71(7-08):237-247. doi: 10.18071/isz.71.0237.

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本文引用的文献

1
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.代谢物 2-羟基戊二酸是 α-酮戊二酸依赖性双加氧酶的竞争性抑制剂。
Cancer Cell. 2011 Jan 18;19(1):17-30. doi: 10.1016/j.ccr.2010.12.014.
2
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.白血病 IDH1 和 IDH2 突变导致超甲基化表型，破坏 TET2 功能，并损害造血分化。
Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9.
3
Cancer-associated IDH mutations: biomarker and therapeutic opportunities.
Biochem Genet. 2024 Dec 4. doi: 10.1007/s10528-024-10974-4.
4
AMPK Deficiency Increases DNA Methylation and Aggravates Colorectal Tumorigenesis in AOM/DSS Mice.AMPK 缺乏导致 AOM/DSS 小鼠的 DNA 甲基化增加并加重结直肠肿瘤发生。
Genes (Basel). 2024 Jun 25;15(7):835. doi: 10.3390/genes15070835.
5
Development and validation of clinical-radiomics analysis for preoperative prediction of IDH mutation status and WHO grade in diffuse gliomas: a consecutive L-[methyl-11C] methionine cohort study with two PET scanners.弥散性 glioma 术前预测 IDH 突变状态和 WHO 分级的临床放射组学分析的开发和验证：两种 PET 扫描仪的连续 L-[甲基-11C]蛋氨酸队列研究。
Eur J Nucl Med Mol Imaging. 2024 Apr;51(5):1423-1435. doi: 10.1007/s00259-023-06562-0. Epub 2023 Dec 19.
6
C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity.C 端结合蛋白 2 作为连接代谢失衡与肥胖发病机制的关键因子浮出水面。
J Atheroscler Thromb. 2024 Feb 1;31(2):109-116. doi: 10.5551/jat.RV22014. Epub 2023 Oct 3.
7
Rational Computational Approaches in Drug Discovery: Potential Inhibitors for Allosteric Regulation of Mutant Isocitrate Dehydrogenase-1 Enzyme in Cancers.理性计算方法在药物发现中的应用：用于癌症中突变型异柠檬酸脱氢酶-1 酶变构调节的潜在抑制剂。
Molecules. 2023 Mar 2;28(5):2315. doi: 10.3390/molecules28052315.
8
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis.L-2 羟戊二酸通过 mTOR-ATF4 轴重塑结直肠癌细胞的氨基酸代谢。
Oncogene. 2023 Apr;42(16):1294-1307. doi: 10.1038/s41388-023-02632-7. Epub 2023 Mar 6.
9
Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2.蛋白激酶 B（PKB/AKT）通过 Nrf2 保护 IDH 突变型脑胶质瘤免受铁死亡。
Clin Cancer Res. 2023 Apr 3;29(7):1305-1316. doi: 10.1158/1078-0432.CCR-22-3179.
10
Biallelic TET2 mutations confer sensitivity to 5'-azacitidine in acute myeloid leukemia.双等位基因 TET2 突变使急性髓系白血病对 5'-氮杂胞苷敏感。
JCI Insight. 2023 Jan 24;8(2):e150368. doi: 10.1172/jci.insight.150368.
癌症相关 IDH 突变：生物标志物和治疗机会。
Oncogene. 2010 Dec 9;29(49):6409-17. doi: 10.1038/onc.2010.444. Epub 2010 Oct 25.
4
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.IDH1 和 IDH2 突变是急性髓系白血病中常见的遗传改变，并且在伴有 NPM1 突变但无 FLT3 内部串联重复的核型正常急性髓系白血病中具有不良预后。
J Clin Oncol. 2010 Aug 1;28(22):3636-43. doi: 10.1200/JCO.2010.28.3762. Epub 2010 Jun 21.
5
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.鉴定出一种 CpG 岛甲基化表型，它定义了神经胶质瘤的一个独特亚群。
Cancer Cell. 2010 May 18;17(5):510-22. doi: 10.1016/j.ccr.2010.03.017. Epub 2010 Apr 15.
6
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.白血病相关 IDH1 和 IDH2 突变的共同特征是一种新的酶活性，可将α-酮戊二酸转化为 2-羟基戊二酸。
Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18.
7
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.癌症相关的 IDH1 突变会产生 2-羟基戊二酸。
Nature. 2009 Dec 10;462(7274):739-44. doi: 10.1038/nature08617.
8
Recurring mutations found by sequencing an acute myeloid leukemia genome.通过对急性髓系白血病基因组进行测序发现的复发性突变。
N Engl J Med. 2009 Sep 10;361(11):1058-66. doi: 10.1056/NEJMoa0903840. Epub 2009 Aug 5.
9
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.IDH1基因中胶质瘤衍生的突变主要抑制IDH1催化活性并诱导缺氧诱导因子-1α（HIF-1α）。
Science. 2009 Apr 10;324(5924):261-5. doi: 10.1126/science.1170944.
10
IDH1 and IDH2 mutations in gliomas.胶质瘤中的异柠檬酸脱氢酶1（IDH1）和异柠檬酸脱氢酶2（IDH2）突变
N Engl J Med. 2009 Feb 19;360(8):765-73. doi: 10.1056/NEJMoa0808710.