多功能蛋白聚糖亚型调节烟碱型乙酰胆碱受体的表达和功能。
Versican isoforms modulate expression and function of nicotinic acetylcholine receptors.
作者信息
Wu Yaojiong, Sheng Wang, Dong Haiheng, Lapierre David, Wan Yudi, Lu Wei-Yang, Yang Burton B
出版信息
Int J Physiol Pathophysiol Pharmacol. 2009 Feb 15;1(1):64-75.
Versican is a chondroitin sulfate proteoglycan whose isoforms are differentially expressed, but little is known of their functions in the neuronal system. Here we show that isoforms of versican play different roles in neuronal differentiation and neurite outgrowth. Expression of versican V1 isoform in PC12 cells induced complete neuronal differentiation and increased the expression of nicotinic acetylcholine receptor in NGF-independent manners. The V1-induced neuronal differentiation was different from the NGF-induced differentiation, showing a specific profile of nAChR subunit expression and distinct kinetics of receptor-gated channel activity. Our results have implications for understanding how versican regulates neuronal development, function and repair.
多功能蛋白聚糖是一种硫酸软骨素蛋白聚糖，其同工型存在差异表达，但人们对它们在神经系统中的功能知之甚少。在此我们表明，多功能蛋白聚糖的同工型在神经元分化和神经突生长中发挥不同作用。多功能蛋白聚糖V1同工型在PC12细胞中的表达诱导了完全的神经元分化，并以不依赖神经生长因子（NGF）的方式增加了烟碱型乙酰胆碱受体的表达。V1诱导的神经元分化不同于NGF诱导的分化，表现出烟碱型乙酰胆碱受体亚基表达的特定模式以及受体门控通道活性的不同动力学。我们的结果对于理解多功能蛋白聚糖如何调节神经元发育、功能和修复具有重要意义。
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