三氟拉嗪对完整大鼠和肾上腺切除大鼠角叉菜胶诱导的急性炎症的影响。
Effect of trifluoperazine on carrageenan-induced acute inflammation in intact and adrenalectomized rats.
作者信息
Mahmoodi Mehdi, Hadad Mohammad Khaksari, Shamsizadeh Ali, Azarang Afrooz, Rayeni Reza Abbasi
出版信息
Int J Physiol Pathophysiol Pharmacol. 2009 Mar 15;1(2):150-153.
Abstract
The aim of present study was to investigate the effect of trifluoperazine (TFP) on carrageenan-induced rat's paw edema in intact and adrenalectomized (ADX). TFP (0.2 and 8 mg/kg) were given intraperitoneally just before the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes and extravasations of Evans blue dye as inflammatory indicators. In both ADX and control groups, administration of TFP reduced inflammatory parameters (paw volume and tissue content of Evans blue dye) in inflamed paw. Our findings suggest that TFP can effectively reduce carrageenan-induced paw edema in both ADX and control rats. Therefore, anti-inflammatory effect of these drugs does not need the adrenal gland activity.
摘要
本研究的目的是调查三氟拉嗪（TFP）对完整和肾上腺切除（ADX）大鼠角叉菜胶诱导的爪部水肿的影响。在足底注射0.1 ml 0.5%角叉菜胶溶液之前，腹腔注射TFP（0.2和8 mg/kg）。4小时后，通过计算爪部体积变化和伊文思蓝染料外渗作为炎症指标来评估爪部水肿。在ADX组和对照组中，TFP给药均降低了炎症参数（爪部体积和伊文思蓝染料组织含量）。我们的研究结果表明，TFP可有效减轻ADX大鼠和对照大鼠角叉菜胶诱导的爪部水肿。因此，这些药物的抗炎作用不需要肾上腺活动。
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本文引用的文献
1
Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases.
Neuropsychopharmacology. 2006 Apr;31(4):853-65. doi: 10.1038/sj.npp.1300911.
2
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.全身使用具有抗痛觉过敏作用的氧化ATP对大鼠炎症爪子中趋化因子表达的抑制作用。
BMC Immunol. 2005 Jul 22;6:18. doi: 10.1186/1471-2172-6-18.
3
On the activity of trifluoperazine and palmitoylcarnitine in mice: delayed hypersensitivity models.关于三氟拉嗪和棕榈酰肉碱在小鼠体内的活性：迟发型超敏反应模型
Life Sci. 2000 Feb 25;66(14):PL183-8. doi: 10.1016/s0024-3205(00)00447-1.
4
Effects of calmodulin antagonists and anesthetics on the skin lesions induced by 2-chloroethylethyl sulfide.钙调蛋白拮抗剂和麻醉剂对2-氯乙基乙基硫醚所致皮肤损伤的影响。
Eur J Pharmacol. 1996 Oct 10;313(1-2):107-14. doi: 10.1016/0014-2999(96)00504-3.
5
Thrombin functions as an inflammatory mediator through activation of its receptor.凝血酶通过激活其受体发挥炎症介质的作用。
J Exp Med. 1996 Mar 1;183(3):821-7. doi: 10.1084/jem.183.3.821.
6
Ethical guidelines for investigations of experimental pain in conscious animals.清醒动物实验性疼痛研究的伦理准则。
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8
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J Pharm Pharmacol. 1988 Jul;40(7):518-20. doi: 10.1111/j.2042-7158.1988.tb05292.x.
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