Banach Mateusz, Prymula Katarzyna, Konieczny Leszek, Roterman Irena
Bioinformation. 2011 Feb 7;5(9):375-7. doi: 10.6026/97320630005375.
The "fuzzy oil drop" model assuming the structure of the hydrophobic core of the form of 3-D Gauss function appeared to be verified positively. The protein 1NMF belonging to downhill proteins was found to represent the hydrophobic density distribution accordant with the assumed model. The accordance of the protein structure with the assumed model was measured using elements of theory information. This observation opens the possibility to simulate the folding process as influenced by external force field of hydrophobic character.
假设疏水核心结构为三维高斯函数形式的“模糊油滴”模型似乎得到了肯定的验证。发现属于下坡蛋白的蛋白质1NMF呈现出与假定模型一致的疏水密度分布。利用理论信息元素来衡量蛋白质结构与假定模型的一致性。这一观察结果为模拟受疏水性外力场影响的折叠过程提供了可能性。