Department of Chemistry, The University of Auckland, Private Bag 92109, Auckland, 1142, New Zealand.
Dalton Trans. 2011 Jul 7;40(25):6591-609. doi: 10.1039/c0dt01711f. Epub 2011 Mar 7.
Metalloporphyrin complexes of the period six metals gold, mercury, thallium, lead and bismuth are often overlooked in favour of their lighter congeners. These complexes exhibit unusual coordination geometries, prominently featuring the metal centre residing out the porphyrin plane. Not only are these compounds chemically interesting, but several applications for these complexes are beginning to emerge. Gold and bismuth porphyrins have medicinal applications including novel chemotherapeutics and sensitizers for α-radiotherapy, while gold porphyrins have applications in materials chemistry and catalysis. This perspective serves to highlight trends in the synthesis and structure of these heavy metal complexes as well as illustrate the considerations necessary for rationally designing elaborate porphyrin architectures.
周期六金属金、汞、铊、铅和铋的金属卟啉配合物通常被忽视，而偏爱它们的较轻同系物。这些配合物具有不寻常的配位几何形状，突出表现为金属中心位于卟啉平面之外。这些化合物不仅在化学上很有趣，而且它们的几种应用也开始出现。金和铋卟啉具有医学应用，包括新型化学治疗剂和用于α-放射治疗的增敏剂，而金卟啉在材料化学和催化中有应用。本观点旨在强调这些重金属配合物的合成和结构趋势，并说明合理设计复杂卟啉结构所需的考虑因素。
