Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and Consumer Sciences, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom, 2520, South Africa.
Inflammation. 2012 Feb;35(1):221-9. doi: 10.1007/s10753-011-9308-6.
Soluble urokinase plasminogen activator receptor (suPAR) is associated with inflammation and may predict lipodystrophy and dysmetabolism in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy. We aimed to assess firstly, whether suPAR levels are elevated in treated and untreated HIV-1-infected Africans compared to uninfected controls at baseline and at a 3-year follow-up, and secondly whether suPAR levels are correlated with cardiovascular and/or metabolic changes. SuPAR, cardiovascular, and metabolic variables were assessed and the percentage change was determined. HIV-1-infected black South Africans had significantly higher suPAR levels than uninfected controls at baseline and at follow-up 3 years later. However, only the treated HIV-1-infected participants showed an increase in suPAR levels at follow-up. The treated group also showed signs of lipodystrophy and their baseline suPAR levels correlated positively with an increased waist circumference. This study indicates that suPAR levels increase and that baseline suPAR is associated with an increase in abdominal fat distribution in HIV-infected black Africans on antiretroviral therapy.
可溶性尿激酶型纤溶酶原激活物受体（suPAR）与炎症有关，可能预测接受抗逆转录病毒治疗的人类免疫缺陷病毒（HIV）感染者的脂肪营养不良和代谢紊乱。我们旨在首先评估在基线和 3 年随访时，与未感染对照组相比，接受治疗和未接受治疗的 HIV-1 感染非洲人 suPAR 水平是否升高，其次评估 suPAR 水平是否与心血管和/或代谢变化相关。评估了 suPAR、心血管和代谢变量，并确定了百分比变化。HIV-1 感染的南非黑人在基线和 3 年后的随访时 suPAR 水平明显高于未感染对照组。然而，只有接受治疗的 HIV-1 感染者在随访时 suPAR 水平升高。治疗组还出现脂肪营养不良的迹象，其基线 suPAR 水平与腰围增加呈正相关。本研究表明，在接受抗逆转录病毒治疗的 HIV 感染的南非黑人中，suPAR 水平升高，且基线 suPAR 与腹部脂肪分布增加有关。
