风湿科就诊人群中糖尿病前期发病率增高：一项回顾性研究。

Increased incidence of pre-diabetes mellitus at a department of rheumatology: a retrospective study.

机构信息

Department of Health Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8520, Japan.

出版信息

Mod Rheumatol. 2011 Oct;21(5):495-9. doi: 10.1007/s10165-011-0433-8. Epub 2011 Mar 8.

DOI:10.1007/s10165-011-0433-8

PMID:21384280

Abstract

We aimed to retrospectively review the incidence of pre-diabetes mellitus (preDM), one of the factors in metabolic syndrome screening, in patients with rheumatic diseases. We examined the levels of hemoglobin A1c (HbA1c) in a total of 498 patients with rheumatic diseases between April 2007 and March 2008 at the Department of Rheumatology in Nagasaki University Hospital. Of the 498 patients, 409 (82.1%) had HbA1c levels higher than 5.6% (National Glycohemoglobin Standardization Program; NGSP) and were recommended for health guidance with a focus on metabolic syndrome. Serum HbA1c levels higher than 6.0%, a possible indicator of DM, were seen in 227 patients (45.6%). Serum HbA1c levels higher than 6.5%, which constitute a high risk for DM, were found in 115 patients (23.1%). PreDM increased gradually with age. Our results suggest that the incidence of preDM may be higher in patients with rheumatic diseases than in patients with other diseases and that these patients should receive healthcare guidance to prevent metabolic syndrome.

摘要

我们旨在回顾风湿性疾病患者中糖尿病前期（preDM）的发病率，这是代谢综合征筛查的因素之一。我们在长崎大学医院风湿病科检查了 2007 年 4 月至 2008 年 3 月期间总共 498 例风湿性疾病患者的糖化血红蛋白（HbA1c）水平。在 498 例患者中，409 例（82.1%）HbA1c 水平高于 5.6%（国家糖化血红蛋白标准化计划；NGSP），建议进行以代谢综合征为重点的健康指导。227 例（45.6%）患者出现血清 HbA1c 水平高于 6.0%，这可能是糖尿病的指标。115 例（23.1%）患者出现 HbA1c 水平高于 6.5%，这构成了糖尿病的高危因素。糖尿病前期随着年龄的增长而逐渐增加。我们的结果表明，风湿性疾病患者的 preDM 发病率可能高于其他疾病患者，这些患者应接受医疗保健指导，以预防代谢综合征。