Stefanicka P, Profant M, Duchaj B, Valach M, Gal V, Dolezal P, Barta T
University ENT Department, Bratislava, Slovakia.
Bratisl Lek Listy. 2010;111(11):590-4.
The aims of the study were to assess our feasibility and accuracy of sentinel lymph node radiolocalization in patients with squamous cell carcinoma of the oral cavity and oropharynx, and to determine whether the pathology of the sentinel node reflected regional disease.
Patients preoperatively underwent lymphoscintigraphy after peritumoral injection of a 99m Tc labeled radiocolloid. After perioperative gamma probe radiolocalization of the sentinel lymph nodes, elective neck dissection was performed. The histopathological examination of the sentinel nodes and other nodes of neck dissection specimen were compared.
Detection of sentinel lymph nodes by lymphoscintigraphy was feasible in all 12 patients. Also localization with a handheld gamma probe was successful in all patients. Forty sentinel nodes and 276 non-sentinel nodes were histopathologically examined. Occult metastases were confirmed in 7 sentinel nodes (4 patients). There was no false negative sentinel lymph node in our series.
Identification of the sentinel lymph node in patients with squamous cell carcinoma of the oral cavity and oropharynx is technically feasible and accurate. This method shows to be able to predict occult metastases and select patients who would benefit from neck dissection (Fig. 1, Tab. 2, Ref. 28). Full Text in free PDF www.bmj.sk.
本研究旨在评估口腔和口咽鳞状细胞癌患者前哨淋巴结放射性定位的可行性和准确性，并确定前哨淋巴结的病理是否反映区域疾病。
患者在肿瘤周围注射99mTc标记的放射性胶体后进行术前淋巴闪烁显像。在前哨淋巴结进行围手术期γ探针放射性定位后，进行选择性颈清扫术。比较前哨淋巴结和颈清扫标本其他淋巴结的组织病理学检查结果。
所有12例患者通过淋巴闪烁显像检测前哨淋巴结均可行。所有患者使用手持式γ探针定位也均成功。对40个前哨淋巴结和276个非前哨淋巴结进行了组织病理学检查。7个前哨淋巴结（4例患者）证实存在隐匿性转移。本系列中无前哨淋巴结假阴性。
口腔和口咽鳞状细胞癌患者前哨淋巴结的识别在技术上可行且准确。该方法能够预测隐匿性转移并选择将从颈清扫术中获益的患者（图1，表2，参考文献28）。全文免费PDF版www.bmj.sk 。
