Hatch K D, Shingleton H M, Austin J M, Boots L R, Younger J B, Soong S J
South Med J. 1978 Nov;71(11):1334-6, 1340. doi: 10.1097/00007611-197811000-00006.
The experience of the Southern Regional Trophoblastic Disease Center includes 222 patients who were referred from January 1972 to October 1977. The initial tissue diagnosis was hydatidiform mole in 212 patients and choriocarcinoma in ten. There was spontaneous remission of 142 (69%) of the moles and one of the choriocarcinomas, and 77 patients developed persistent trophoblastic disease. Of these, 58 had no evidence of metastasis, and all achieved remission with single-drug therapy. Nineteen patients developed metastases; 13 were in the "good prognosis" category, and all achieved remission with single-drug therapy. Five (83%) of the six patients with metastases in the "poor prognosis" group achieved remission with triple chemotherapy; one died of her disease.
南方地区滋养细胞疾病中心的经验涵盖了1972年1月至1977年10月转诊的222例患者。最初的组织诊断为212例葡萄胎和10例绒毛膜癌。142例（69%）葡萄胎和1例绒毛膜癌出现自发缓解，77例患者发展为持续性滋养细胞疾病。其中，58例无转移证据，均通过单药治疗实现缓解。19例患者发生转移；13例属于“预后良好”类别，均通过单药治疗实现缓解。“预后不良”组6例转移患者中有5例（83%）通过三联化疗实现缓解；1例死于该病。
