Department of Anaesthesia and Intensive Care, Baerum Hospital, Rud, Norway.
Acta Anaesthesiol Scand. 2011 May;55(5):571-6. doi: 10.1111/j.1399-6576.2011.02410.x. Epub 2011 Mar 8.
Pregabalin acts as a membrane stabilizer and has both analgesic and anxiolytic effects. We hypothesized that one pre-operative dose of pregabalin would reduce pre-operative anxiety and post-operative pain in patients undergoing discectomy.
We performed a randomized, placebo-controlled study of 150 mg pregabalin administered before lumbar discectomy in general anaesthesia. The primary endpoint was pain at rest [visual analogue scale (VAS)] 120 min after surgery. The secondary outcomes were morphine consumption, pre-operative anxiety (VAS) and the occurrence of side effects.
The VAS scores for pain at rest and morphine consumption were higher in the placebo group during the 4-h stay in the post-anaesthetic care unit (PACU), but did not differ significantly 24 h after surgery. Pain scores at 7 days were similar and there was no difference in the occurrence of side effects. Pre-operative anxiety was significantly lower in the pregabalin group (2.23±1.11 vs. 4.17±2.37, 95% confidence interval: 0.82-3.05, P=0.001) and there was a significant positive correlation between the pre-operative anxiety score and post-operative pain at 120 min in the pregabalin group.
A single dose of pregabalin (150 mg) reduced post-operative pain at rest and morphine consumption during the PACU period after lumbar discectomy. Pre-operative anxiety was lower, without increased incidence of side effects.
普瑞巴林作为一种膜稳定剂，具有镇痛和抗焦虑作用。我们假设术前给予一次普瑞巴林剂量会减少行椎间盘切除术患者的术前焦虑和术后疼痛。
我们进行了一项随机、安慰剂对照研究，在全身麻醉下对 150mg 普瑞巴林进行腰椎间盘切除术。主要终点是术后 120 分钟静息时疼痛[视觉模拟评分（VAS）]。次要结局是吗啡消耗量、术前焦虑（VAS）和副作用的发生。
在麻醉后护理病房（PACU）停留的 4 小时内，安慰剂组的静息时疼痛 VAS 评分和吗啡消耗量较高，但术后 24 小时无显著差异。7 天的疼痛评分相似，且副作用的发生无差异。普瑞巴林组术前焦虑显著降低（2.23±1.11 与 4.17±2.37，95%置信区间：0.82-3.05，P=0.001），且普瑞巴林组术前焦虑评分与术后 120 分钟静息时疼痛呈显著正相关。
单次剂量的普瑞巴林（150mg）可减少腰椎间盘切除术后 PACU 期间的静息时疼痛和吗啡消耗量。术前焦虑降低，且副作用发生率无增加。
