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复发性胫骨皮质内骨肉瘤:一例报告并文献复习

Recurrent tibial intra-cortical osteosarcoma: a case report and review of the literature.

作者信息

Arpornchayanon Olarn, Leerapun Taninnit, Sivasomboon Chate, Settakorn Jongkolnee, Sugandhavesa Nantawit, Pruksakorn Dumnoensun

机构信息

Musculoskeletal Oncology Division, Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Suthep Road, Chiang Mai TH-50200, Thailand.

出版信息

J Med Case Rep. 2011 Mar 7;5:93. doi: 10.1186/1752-1947-5-93.

Abstract

INTRODUCTION

Intra-cortical osteosarcoma is the rarest subtype of osseous-producing tumor. Most reported cases present a low-grade histology with slow progression and good oncological control after adequate treatment. In this report, we describe a case and review the literature to propose adequate treatment.

CASE PRESENTATION

We present the case of a 21-year-old Thai woman who was thought to have an intra-cortical osteosarcoma of the right tibia. We performed a wide resection and reconstruction with bone transportation using an Ilizarov external fixator. The tumor recurred five years later at the same site with a similar histology. We performed a new resection and reconstruction by ankle arthrodesis with adjuvant chemotherapy. At the last follow-up, she had remained active and free from disease for seven years.

CONCLUSION

This case report of recurrent intra-cortical osteosarcoma describes an atypical presentation. The low-grade histology, adequate surgical margin and adjuvant chemotherapy of the recurrent lesion were favorable factors, and our patient has remained free of any tumor recurrence.

摘要

引言

皮质内骨肉瘤是骨生成性肿瘤中最罕见的亚型。大多数报道的病例组织学分级较低,进展缓慢,经过充分治疗后肿瘤学控制良好。在本报告中,我们描述了一例病例并回顾文献以提出适当的治疗方法。

病例介绍

我们报告一例21岁泰国女性,被诊断为右胫骨皮质内骨肉瘤。我们采用Ilizarov外固定架进行了广泛切除并通过骨搬运进行重建。五年后肿瘤在同一部位复发,组织学表现相似。我们通过踝关节融合术并辅助化疗进行了新的切除和重建。在最后一次随访时,她保持活跃状态,且已无病生存七年。

结论

本复发性皮质内骨肉瘤病例报告描述了一种非典型表现。复发病变的低级别组织学、足够的手术切缘和辅助化疗是有利因素,我们的患者未出现任何肿瘤复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d35/3060852/7d505334b83a/1752-1947-5-93-1.jpg

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