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Selection of Suitable Reference Genes for qPCR Gene Expression Analysis of HepG2 and L02 in Four Different Liver Cell Injured Models.四种不同肝损伤模型中 HepG2 和 L02 细胞 qPCR 基因表达分析中合适内参基因的选择。
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Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues.利用数据非依赖采集扩展定量蛋白质组分析的极限并应用于对乙酰氨基酚处理的三维肝脏微组织
Mol Cell Proteomics. 2015 May;14(5):1400-10. doi: 10.1074/mcp.M114.044305. Epub 2015 Feb 27.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.近年来，利用原代肝细胞、替代的肝细胞来源和非实质细胞的 2D 和 3D 体外系统在研究肝毒性、细胞信号转导和 ADME 的机制方面取得了进展。
Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.

本文引用的文献

1
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.HepaRG 细胞：研究对乙酰氨基酚肝毒性机制的人类模型。
Hepatology. 2011 Mar;53(3):974-82. doi: 10.1002/hep.24132. Epub 2011 Feb 11.
2
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.药物诱导的 HepG2 细胞肝毒性的蛋白质组学研究。
Toxicol Sci. 2011 Mar;120(1):109-22. doi: 10.1093/toxsci/kfq380. Epub 2010 Dec 16.
3
Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes: a cautionary note on the impact of cell culture conditions.对乙酰氨基酚诱导小鼠肝细胞线粒体损伤和毒性中的活性氮物质：关于细胞培养条件影响的警示
Chem Res Toxicol. 2010 Dec 20;23(12):1853-4; author reply 1855-8. doi: 10.1021/tx100310b.
4
The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.氧张力调节乙酰氨基酚诱导的肝细胞线粒体氧化应激和细胞损伤。
Toxicol Sci. 2010 Oct;117(2):515-23. doi: 10.1093/toxsci/kfq208. Epub 2010 Jul 8.
5
Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice.二甲基亚砜对小鼠对乙酰氨基酚代谢及毒性的影响。
Biol Pharm Bull. 2006 Aug;29(8):1618-24. doi: 10.1248/bpb.29.1618.
6
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.急性肝衰竭患者血清对乙酰氨基酚 - 蛋白质加合物的测定。
Gastroenterology. 2006 Mar;130(3):687-94. doi: 10.1053/j.gastro.2006.01.033.
7
Role of caspases in acetaminophen-induced liver injury.半胱天冬酶在对乙酰氨基酚诱导的肝损伤中的作用。
Life Sci. 2006 Mar 6;78(15):1670-6. doi: 10.1016/j.lfs.2005.07.003. Epub 2005 Oct 13.
8
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.对乙酰氨基酚诱导肝细胞死亡的细胞内信号传导机制。
Toxicol Sci. 2006 Jan;89(1):31-41. doi: 10.1093/toxsci/kfi336. Epub 2005 Sep 21.
9
Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake.100种参考化合物对肝癌细胞系Hep G2和人宫颈癌HeLa细胞的细胞毒性作用，以及60种化合物对人子宫内膜癌细胞系ECC - 1和仓鼠卵巢细胞系CHO细胞的细胞毒性作用。关于活性氧（ROS）、谷胱甘肽消耗和钙黄绿素摄取的机制分析。
Toxicol In Vitro. 2005 Jun;19(4):505-16. doi: 10.1016/j.tiv.2005.01.003.
10
Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents.110种参考化合物对HepG2细胞的细胞毒性作用，以及60种化合物对HeLa、ECC-1和CHO细胞的细胞毒性作用。二、关于NAD(P)H、ATP和DNA含量的作用机制分析
Toxicol In Vitro. 2005 Jun;19(4):491-503. doi: 10.1016/j.tiv.2005.01.002.

Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

作者信息

Jaeschke Hartmut, McGill Mitchell R, Ramachandran Anup

出版信息

Toxicol Sci. 2011 Jun;121(2):428-30; author reply 431-3. doi: 10.1093/toxsci/kfr053. Epub 2011 Mar 7.

DOI:10.1093/toxsci/kfr053
PMID:21385733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6280871/
Abstract
摘要