Laboratory of Cell Signaling, University of Campinas, Campinas, São Paulo, Brazil.
Int J Obes (Lond). 2011 Dec;35(12):1455-65. doi: 10.1038/ijo.2011.56. Epub 2011 Mar 8.
Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure.
能量平衡涉及一个复杂的下丘脑和下丘脑外神经元网络，这些神经元将激素、营养和神经元信号转化为反应，最终使热量摄入与能量消耗相匹配，从而促进体脂肪储存的稳定性。越来越多的证据表明，常见的肥胖形式并不是反映出调节热量摄入的失败，而是涉及到这种体内平衡系统的根本变化，有利于维持高水平的体脂肪。本文综述了新出现的证据，即在高脂肪喂养期间，肥胖发病机制涉及调节食物摄入和能量消耗的下丘脑系统的根本改变。
