Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.
Chem Commun (Camb). 2011 Apr 21;47(15):4457-9. doi: 10.1039/c1cc10337g. Epub 2011 Mar 9.
Controllable exploding polyelectrolyte microcapsules were developed by layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on a dextran microgel core containing a cleavable disulfide bond fabricated via click chemistry. The microcapsules can explode upon the injection of DTT with an explosive release of the drug.
可控制的爆炸型聚电解质微胶囊是通过层层组装聚(盐酸烯丙胺)（PAH）和聚(4-苯乙烯磺酸钠)（PSS）在含有可通过点击化学构建的可裂解二硫键的葡聚糖微凝胶核上制备的。这些微胶囊在注射 DTT 时会发生爆炸，从而使药物迅速释放。
