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经颅磁刺激治疗抑郁症的疗效

[The efficacy of transcranial magnetic stimulation in the treatment of depression].

作者信息

Zyss Tomasz, Zieba Andrzej, Dudek Dominika, Datka Wojciech, Siwek Marcin, Wróbel Andrzej, Grabski Bartosz, Maczka Grzegorz, Brudkiewicz Paweł, Wojnar Norbert, Łaczyrska Maja, Borowiecka-Kluza Joanna, Zygmuntowicz Marcin, Polański Adam

机构信息

Klinika Psychiatrii Doroslych, Szpital Uniwersytecki CM UJ, Kraków.

出版信息

Przegl Lek. 2010;67(9):666-73.

PMID:21387802
Abstract

BACKGROUND

Transcranial magnetic stimulation (TMS) is known as method of depression therapy.

RESULTS

The paper presents the results of clinical 2nd phase investigation or safety and efficacy of TMS as compared to electroconvulsive therapy and standalone pharmacotherapy.

RESULTS

It was shown that in all three groups of patients a significant improvement of clinical state (decrease of depressive symptoms) was achieved. The strongest effect was observed in the group of patients treated with electroconvulsive therapy (as well as drugs). However, trans-cranial magnetic stimulation combined with pharmacotherapy did not prove to be more effective than standalons pharmacological treatment. The authors discuss possible explanations of inefficacy of transcranial magnetic stimulation therapy.

CONCLUSIONS

None antidepressive efficacy of TMS was observed. Forthcoming examinations of TMS are necessary for optimalization of stimulation parameters and conditions.

摘要

背景

经颅磁刺激(TMS)是一种已知的抑郁症治疗方法。

结果

本文呈现了经颅磁刺激与电休克疗法及单独药物治疗相比的临床二期安全性和有效性调查结果。

结果

结果显示,在所有三组患者中,临床状态均有显著改善(抑郁症状减轻)。在接受电休克疗法(以及药物)治疗的患者组中观察到最强效果。然而,经颅磁刺激联合药物治疗并未被证明比单独药物治疗更有效。作者讨论了经颅磁刺激疗法无效的可能原因。

结论

未观察到经颅磁刺激的抗抑郁效果。有必要对经颅磁刺激进行进一步检查以优化刺激参数和条件。

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