Hansen Anders E, McEvoy Fintan, Engelholm Svend A, Law Ian, Kristensen Annemarie T
Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Dyrlaegevej 16, Frederiksberg C 1870, Denmark.
Vet Radiol Ultrasound. 2011 Mar-Apr;52(2):201-6. doi: 10.1111/j.1740-8261.2010.01757.x. Epub 2010 Oct 26.
2-Deoxy-2-[¹⁸F]fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT) is becoming increasingly available as an imaging modality in veterinary medicine. The purpose of this study was to report semiquantitative standard uptake values (SUV) of malignant and nonmalignant tissues and organs in canine cancer patients. FDG PET/CT was performed in 14 dogs including, nine mesenchymal tumors, four carcinomas, and one incompletely excised mast cell tumor. A generally higher FDG uptake was observed in carcinomas relative to sarcomas. Maximum SUV of carcinomas ranged from 7.6 to 27.0, and for sarcomas from 2.0 to 10.6. The FDG SUV of several organs and tissues, including regional brain uptake is reported, to serve as a reference for future FDG PET studies in canine cancer patients. Several potential pitfalls have been recognized in interpretation of FDG PET images of human patients, a number of these were also observed in this study.
2-脱氧-2-[¹⁸F]氟-D-葡萄糖正电子发射断层扫描/计算机断层扫描(FDG PET/CT)在兽医学中作为一种成像方式越来越普及。本研究的目的是报告犬类癌症患者恶性和非恶性组织及器官的半定量标准化摄取值(SUV)。对14只犬进行了FDG PET/CT检查,其中包括9只间充质肿瘤、4只癌和1只未完全切除的肥大细胞瘤。相对于肉瘤,癌组织中通常观察到更高的FDG摄取。癌组织的最大SUV范围为7.6至27.0,肉瘤的最大SUV范围为2.0至10.6。报告了包括局部脑摄取在内的多个器官和组织的FDG SUV,为未来犬类癌症患者的FDG PET研究提供参考。在解读人类患者的FDG PET图像时已经认识到一些潜在的陷阱,本研究中也观察到了其中的一些。