Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 28644, South Korea.
Department of Veterinary Imaging, Veterinary Teaching Hospital, College of Veterinary Medicine, Cheongju, Chungbuk, 28644, South Korea.
BMC Vet Res. 2022 Jan 3;18(1):15. doi: 10.1186/s12917-021-03102-6.
In human medicine, 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been used to differentiate between benign and malignant adrenal tumors and to identify metastases. However, canine adrenocortical carcinomas identified by 18F-FDG PET/computed tomography (CT) have not been reported.
A 13-year-old, castrated male, Cocker Spaniel dog with severe systolic hypertension exhibited an adrenal mass approximately 3.6 cm in diameter on ultrasonography. There was no evidence of pulmonary metastasis or vascular invasion on thoracic radiography and abdominal ultrasonography, respectively. 18F-FDG PET/CT was performed to identify the characteristics of the adrenal mass and the state of metastasis. One hour after injection of 5.46 MBq/kg 18F-FDG intravenously, the peripheral region of the adrenal mass visually revealed an increased 18F-FDG uptake, which was higher than that of the liver, and the central region of the mass exhibited necrosis. The maximal standardized uptake value (SUV) of the adrenal mass was 3.24; and relative SUV, calculated by dividing the maximal SUV of the adrenal tumor by the mean SUV of the normal liver, was 5.23. Adrenocortical carcinoma was tentatively diagnosed and surgical adrenalectomy was performed. Histopathologic examination of the resected adrenal mass revealed the characteristics of an adrenocortical carcinoma. After adrenalectomy, systolic blood pressure reduced to below 150 mmHg without any medication.
This is the first case report of 18F-FDG PET/CT findings in a dog with suspected adrenocortical carcinoma and may provide valuable diagnostic information for adrenocortical carcinoma in dogs.
在人类医学中，18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）已被用于区分良恶性肾上腺肿瘤并确定转移灶。然而，尚未有犬肾上腺皮质癌通过 18F-FDG PET/计算机断层扫描（CT）得到报道。
一只 13 岁、已去势的雄性可卡犬，患有严重的收缩期高血压，超声检查发现直径约 3.6cm 的肾上腺肿块。胸部 X 射线和腹部超声检查分别未见肺转移或血管侵犯的证据。为了确定肾上腺肿块的特征和转移状态，进行了 18F-FDG PET/CT 检查。静脉注射 5.46MBq/kg 18F-FDG 后 1 小时，肾上腺肿块的外周区域可见 18F-FDG 摄取增加，视觉上高于肝脏，肿块的中央区域出现坏死。肾上腺肿块的最大标准化摄取值（SUV）为 3.24；通过将肾上腺肿瘤的最大 SUV 除以正常肝脏的平均 SUV 计算得出的相对 SUV 为 5.23。初步诊断为肾上腺皮质癌，并进行了肾上腺切除术。切除的肾上腺肿块的组织病理学检查显示出肾上腺皮质癌的特征。肾上腺切除术后，收缩压降至 150mmHg 以下，无需任何药物治疗。
这是首例疑似犬肾上腺皮质癌的 18F-FDG PET/CT 检查结果的病例报告，可为犬肾上腺皮质癌提供有价值的诊断信息。
