Division of Mohs Micrographic Surgery, Department of Dermatology, Henry Ford Health System, Detroit, Michigan 48202, USA.
Dermatol Surg. 2011 Apr;37(4):426-31. doi: 10.1111/j.1524-4725.2011.01918.x. Epub 2011 Mar 9.
Subcuticular incision is performed to release fibrotic bands beneath acne scars and to stimulate neocollagenesis. Naturally sourced porcine collagen has been approved for filling moderate to deep facial wrinkles and nasolabial folds. To our knowledge, naturally sourced porcine collagen filler has not yet been tried as a treatment for correcting atrophic acne scars.
To objectively assess and directly compare the efficacy and safety of subcuticular incision versus naturally sourced porcine collagen dermal filler in correcting atrophic and rolling acne scars.
We performed a prospective, randomized, split-face, single-blind study to evaluate intermediate long-term efficacy of subcision and collagen dermal filler on 20 unilateral faces. Patients and blinded physicians evaluated results.
Patients rated subcision as superior to collagen dermal filler at 3 months (p=.03). At 6 months, subcision had a slightly higher rating than collagen dermal filler (p=.12). Blinded evaluators leaned toward subcision at 3 months (p=.12) and at 6 months showed no preference (p=.69).
Subcuticular incision and naturally sourced porcine collagen dermal filler appear to be efficacious for improving atrophic and rolling acne scars. Patients may prefer subcuticular incision over collagen dermal filler. Blinded evaluators found no significant difference between the treatments.
皮下切开术用于释放痤疮疤痕下的纤维带，并刺激新胶原生成。天然来源的猪胶原蛋白已被批准用于填充中度至深度面部皱纹和鼻唇沟。据我们所知，天然来源的猪胶原蛋白填充剂尚未尝试用于治疗萎缩性痤疮疤痕。
客观评估和直接比较皮下切开术与天然来源猪胶原蛋白真皮填充剂在纠正萎缩性和滚动性痤疮疤痕方面的疗效和安全性。
我们进行了一项前瞻性、随机、分面、单盲研究，以评估皮下切开术和胶原蛋白真皮填充剂对 20 张单侧面部的中期长期疗效。患者和盲法医生评估了结果。
患者在 3 个月时将皮下切开术评为优于胶原蛋白真皮填充剂（p=.03）。6 个月时，皮下切开术的评分略高于胶原蛋白真皮填充剂（p=.12）。盲法评估者在 3 个月时倾向于皮下切开术（p=.12），而在 6 个月时没有偏好（p=.69）。
皮下切开术和天然来源猪胶原蛋白真皮填充剂似乎可有效改善萎缩性和滚动性痤疮疤痕。患者可能更喜欢皮下切开术而不是胶原蛋白真皮填充剂。盲法评估者发现两种治疗方法之间没有显著差异。
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