Alcamí José, Coiras Mayte
Unidad de Inmunopatología del Sida, Instituto de Salud Carlos III, Majadahonda, Madrid, España.
Enferm Infecc Microbiol Clin. 2011 Mar;29(3):216-26. doi: 10.1016/j.eimc.2011.01.006.
Killing of CD4 lymphocytes and systemic immune suppression are the hallmarks of HIV infection. These milestones are produced by different mechanisms that draw a complex picture of AIDS immunopathogenesis. The role of the GALT system as a preferential target for HIV, chronic activation of the immune system and viral escape mechanisms are recent challenges that have changed our current view on the mechanisms leading to immune destruction and development of AIDS. In this article, the mechanisms of immune suppression, the evolution of immune response throughout the infection and the mechanisms of viral escape are analysed.
CD4淋巴细胞的杀伤和全身免疫抑制是HIV感染的标志。这些标志性事件是由不同机制产生的，描绘了一幅复杂的艾滋病免疫发病机制图景。GALT系统作为HIV的优先靶标、免疫系统的慢性激活以及病毒逃逸机制的作用，是最近出现的挑战，它们改变了我们目前对导致免疫破坏和艾滋病发展机制的看法。在本文中，我们分析了免疫抑制机制、感染全过程中免疫反应的演变以及病毒逃逸机制。
