马来亚癫痫患者 ABCB1 多态性与丙戊酸钠治疗反应的关系。
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients.
机构信息
Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Epileptic Disord. 2011 Mar;13(1):65-75. doi: 10.1684/epd.2011.0419.
Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30% of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypes were assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.
P-糖蛋白（P-glycoprotein）的过度表达，由 ABCB1 基因编码，被认为与约 30%的癫痫患者对抗癫痫药物的耐药性有关。在这里，我们研究了 ABCB1 多态性与马来西亚癫痫患者中丙戊酸钠（VPA）治疗之间的可能关联。在 249 例耐药性和 256 例药物反应性马来西亚患者中，评估了 ABCB1 基因中的 C1236T、G2677T/A 和 C5T 多态性的基因型。在总体组或华人、印度人和马来人亚组中，均未发现基因型、等位基因或单倍型与 VPA 的反应相关。我们的数据表明，ABCB1 基因中的 C1236T、G2677T/A 和 C3435T 多态性与癫痫患者对 VPA 的反应无关。
Zotero 插件