Timing of valve replacement in chronic aortic regurgitation. A pathophysiological approach.

Timing of valve replacement (AVR) in chronic aortic regurgitation remains a difficult problem in clinical practice. When the disease takes a favorable natural course, this may be attributed to excellent compensatory mechanisms - especially an increase in left ventricular end-diastolic volume (LVEDV) in relation to regurgitant volume (RV) - whereas a rapid clinical and hemodynamic deterioration may usually be ascribed to a vicious circle consisting in a marked increase in afterload leading to an increase in LVEDV and so on. 54 patients with aortic regurgitation underwent pre- and postoperative as well as long-term follow-up radionuclide ventriculographic (RNV) studies in order to determine LVEDV and RV and to measure left ventricular ejection fraction (LVEF). These measures were expected to provide information on 'physiologic' LVEDV elevation in relation to RV. Our results indicate that if LVEDV exceeds 300-400 ml there may be an increase in afterload for LV. Factors counteracting this increased afterload (LV hypertrophy, increased diastolic stretching) will eventually preserve LVEF and keep LVEDV/RV within the normal range, but are accompanied by an elevation of LV filling pressure leading to dyspnea on exertion. With an LVEDV exceeding 400-500 ml these factors generally cannot prevent the initiation of the above mentioned vicious circle. Hence, in these severely symptomatic cases LVEDV/RV exceeds the normal range and LVEF becomes markedly depressed. An unfavorable postoperative result must be expected in these patients, while the postoperative result will be good in cases with an LVEDV/RV within the normal range. Hence, we conclude that AVR should ideally be performed in those patients with an EDV exceeding 300 ml, who still have an LVEDV/RV within the normal range, but who show clinical symptoms and/or an only moderately depressed LVEF, indicating that the limits of the compensatory mechanism are reached. The indications for AVR in other conditions characterized by the clinical status, the level of the LVEDV and LVEDV/RV are discussed.