墨西哥儿童侵袭性疾病肺炎链球菌分离株的血清型及抗生素敏感性
Serotypes and antibiotic susceptibility of Streptococcus pneumoniae isolates causative of invasive diseases in Mexican children.
作者信息
Arredondo-García José Luis, Calderón Ernesto, Echániz-Aviles Gabriela, Soto-Noguerón Araceli, Arzate Patricia, Amabile-Cuevas Carlos F
机构信息
Instituto Nacional de Pediatría, Mexico City, Mexico.
出版信息
J Infect Dev Ctries. 2011 Mar 2;5(2):119-22. doi: 10.3855/jidc.1348.
INTRODUCTION
Streptococcus pneumoniae is a worldwide leading cause of morbidity and mortality, while susceptibility towards penicillin and macrolides can be less than 50% in many regions.
METHODOLOGY
A total of 150 isolates of S. pneumoniae causative of invasive diseases in children were characterized, of which 24.6% had a fatal outcome.
RESULTS
The most prevalent serotypes were 19F, 6B, 23F and 14. Resistance to penicillin, erythromycin (mostly of macrolide-lincosamide-streptogramin resistance phenotype) or trimethoprim-sulfamethoxazole was found in more than 40% of the isolates, but no resistance phenotype appeared linked to lethality. Serotype 3 isolates, which were seldom resistant, had a twofold lethality rate compared to the total sample.
CONCLUSION
Serotyping could provide a better outcome-predicting tool than susceptibility testing. The seven-valent vaccine does not include the most prevalent serotypes found in Mexico.
引言
肺炎链球菌是全球发病率和死亡率的主要原因，而在许多地区，其对青霉素和大环内酯类药物的敏感性可能低于50%。
方法
对150株导致儿童侵袭性疾病的肺炎链球菌分离株进行了特征分析，其中24.6%的病例出现致命结果。
结果
最常见的血清型为19F、6B、23F和14。超过40%的分离株对青霉素、红霉素（主要为大环内酯-林可酰胺-链阳菌素耐药表型）或甲氧苄啶-磺胺甲恶唑耐药，但未发现耐药表型与致死率相关。血清型3分离株很少耐药，但其致死率是总样本的两倍。
结论
血清分型可能比药敏试验提供更好的结果预测工具。七价疫苗不包括在墨西哥发现的最常见血清型。
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