Krezel Michael Angus, Rezmann Linda Adriana, Varghayee Naghmeh, Pete Josefa, Frauman Albert George, Louis Simon Nicholas Stewart
Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health, Heidelberg, Victoria, Australia.
Biosci Biotechnol Biochem. 2011;75(3):414-8. doi: 10.1271/bbb.100176. Epub 2011 Mar 7.
To investigate the expression of the unknown angiotensin II type 2 receptor interacting protein (ATIP) isoforms in the rat we used the known sequences of human and mouse ATIP to design sequencing primers to enable us to sequence rat ATIP3 and ATIP4. Exon 4, which is present in human but not mouse ATIP, was not identified in the coding region of rat ATIP. The expression levels of these genes in a range of rat tissues were examined, and we concluded that there is little similarity in the relative tissue distribution of the various ATIP isoforms in rat and human.
为了研究未知的血管紧张素II 2型受体相互作用蛋白（ATIP）亚型在大鼠中的表达情况，我们利用人和小鼠ATIP的已知序列设计测序引物，以便对大鼠ATIP3和ATIP4进行测序。在大鼠ATIP的编码区未发现人ATIP中存在但小鼠ATIP中不存在的外显子4。我们检测了这些基因在一系列大鼠组织中的表达水平，并得出结论，大鼠和人类中各种ATIP亚型的相对组织分布几乎没有相似性。
