Academic Medical Center, Medical Biochemistry, University of Amsterdam, Amsterdam, The Netherlands
Autophagy. 2011 Aug;7(8):805-13. doi: 10.4161/auto.7.8.15192. Epub 2011 Aug 1.
Now that many of the components of the autophagy machinery have been identified, in particular the autophagy-related (Atg) proteins, increasing focus is being directed toward the role of autophagy in health and disease. Accordingly, it is of ever-greater importance to understand the central role of autophagy in cellular metabolism, a point with which many people will likely agree. However, in our rush to understand autophagy's function in metabolism, we tend to overlook the role of metabolism in regulating autophagy, even though substantial work has been done on this topic. One of the pioneers in this area is Alfred "Fred" J. Meijer.
现在已经鉴定出了许多自噬机制的组成部分，尤其是自噬相关（Atg）蛋白，因此人们越来越关注自噬在健康和疾病中的作用。相应地，理解自噬在细胞代谢中的核心作用变得愈发重要，这一点可能很多人都会认同。然而，在我们急于了解自噬在代谢中的功能时，往往会忽略代谢在调节自噬中的作用，尽管这个话题已经有大量的研究。在这个领域的先驱之一是阿尔弗雷德（Alfred）“弗雷德”（Fred）·J·梅杰（Meijer）。
