Department of Anesthesiology and Pain Medicine, Bucheon Hospital, College of Medicine, Soonchunhyang University, Bucheon, Korea.
Korean J Pain. 2011 Mar;24(1):53-6. doi: 10.3344/kjp.2011.24.1.53. Epub 2011 Feb 25.
Although postherpetic neuralgia (PHN) is a common chronic pain syndrome, the pathophysiology of this disorder is not well known and management is often very difficult. N-Methyl-D-Aspartate (NMDA) receptor antagonists are known to be effective in PHN, and magnesium, a physiological blocker of NMDA receptors, is widely used to treat various chronic pain disorders. Here, we present a case of the PHN refractory to conventional treatment, which was treated successfully with transforaminal epidural injection of magnesium sulphate at the affected dermatome.
虽然带状疱疹后神经痛 (PHN) 是一种常见的慢性疼痛综合征,但该疾病的病理生理学尚不清楚,治疗通常非常困难。已知 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂对 PHN 有效,而镁作为 NMDA 受体的生理性阻断剂,被广泛用于治疗各种慢性疼痛疾病。在这里,我们报告了一例常规治疗无效的 PHN 病例,在受累皮区经椎间孔硬膜外注射硫酸镁后成功治疗。