Bertrand E, Schlatter J
Jean Verdier University Hospital, Bondy, France.
Pharmazie. 2011 Jan;66(1):75-9.
Transmissible spongiform encephalopathy (TSE) is a degenerative disease of the central nervous system. As yet, there is no human screening test and no effective treatment. This disease is invariably fatal. General preventive measures are therefore essential. The objective of this study is to analyze and address on a prioritized basis the risks relating to the transmission of Creutzfeldt-Jakob disease during surgical operations by means of a preliminary risk analysis (PRA). The PRA produces 63 scenarios with maximum risk relating to operational and legal dangers. The study recommends a number of courses of action, such as training and internal controls, in order to reduce the risks identified. A procedure has been drawn up and assessed for each action. This PRA makes it possible to target and significantly reduce the potential dangers for transmission of Creutzfeldt-Jakob disease through the use of medical instruments.
可传播性海绵状脑病（TSE）是一种中枢神经系统退行性疾病。目前，尚无针对人类的筛查测试，也没有有效的治疗方法。这种疾病无一例外都是致命的。因此，一般预防措施至关重要。本研究的目的是通过初步风险分析（PRA），对手术过程中克雅氏病传播相关风险进行分析，并按优先级加以应对。PRA产生了63种与操作和法律风险相关的最大风险情景。该研究推荐了一些行动方案，如培训和内部控制，以降低已识别的风险。已为每项行动制定并评估了一个程序。通过使用医疗仪器，这种PRA能够针对并显著降低克雅氏病传播的潜在风险。
