心房利钠肽对大鼠垂体前叶和神经中间叶腺苷酸环化酶活性的影响。
Effect of atrial natriuretic peptide on the adenylate cyclase activity in the anterior and neurointermediate pituitary lobes of rats.
作者信息
Geiger H, Bahner U, Palkovits M, Hempel K
机构信息
Department of Nephrology, University of Würzburg, FRG.
出版信息
Miner Electrolyte Metab. 1990;16(1):38-41.
The effect of two atrial natriuretic peptides, rat ANP (3-28) and synthetic ANP (Arg101-Tyr126), on pituitary adenylate cyclase activity was measured in rats. Neither one was effective on basal, forskolin- or guanylylimidodiphosphate (GMP-PNP)-stimulated adenylate cyclase levels measured in homogenates of anterior and neurointermediate pituitary lobes. High concentrations (10(-7) and 10(-6) M) of ANPs further stimulate NaF-induced high adenylate cyclase activity - ANP (3-28) in both lobes, ANP (Arg101-Tyr126) only in the anterior lobe-but they were without effect in 10(-8) M or lower concentrations. These data indicate that ANP may not influence adenylate cyclase/cAMP system in the rat pituitary gland.
在大鼠中测量了两种心房利钠肽，即大鼠ANP（3 - 28）和合成ANP（精氨酸101 - 酪氨酸126）对垂体腺苷酸环化酶活性的影响。在垂体前叶和神经中间叶匀浆中测得的基础、福斯高林或鸟苷酰亚胺二磷酸（GMP - PNP）刺激的腺苷酸环化酶水平上，这两种肽均无效。高浓度（10⁻⁷和10⁻⁶ M）的心房利钠肽进一步刺激了氟化钠诱导的高腺苷酸环化酶活性——在两个叶中ANP（3 - 28）均可，ANP（精氨酸101 - 酪氨酸126）仅在前叶中有效——但在10⁻⁸ M或更低浓度时它们无作用。这些数据表明心房利钠肽可能不会影响大鼠垂体中的腺苷酸环化酶/cAMP系统。
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