Department of Physical Education and Sport, School of Physical Activity and Sport Sciences, University of Granada, Granada, Spain.
Br J Nutr. 2011 Aug;106(4):486-90. doi: 10.1017/S0007114511000432. Epub 2011 Mar 11.
The aim of the present study was to investigate the association of PLIN1 11482G>A (rs894160) and PLIN1 13041A>G (rs2304795) polymorphisms with body composition, energy and substrate metabolism, and the metabolic response to a 12-week energy-restricted diet in obese women. The study comprised a total of seventy-eight obese (BMI 34·0 (SD 2·8) kg/m(2)) women (age 36·7 (SD 7) years). We measured weight, height and waist circumference before and after a 12-week controlled energy-restricted diet intervention. Body fat mass and lean mass were measured by dual-energy X-ray absorptiometry. RMR and lipid oxidation rate were measured by indirect calorimetry. We also analysed fasting plasma glucose, insulin, cholesterol and leptin. Women carrying the 11482A allele had a lower reduction in waist circumference than non-A allele carriers (3·2 (SD 0·5) v. 4·6 (SD 0·6) %, respectively, P = 0·047; P for gene-diet interaction = 0·064). Moreover, women with the 11482A allele had a higher decrease in lipid oxidation rate than non-A allele carriers (58·9 (SD 6·7) v. 31·3 (SD 8·2) %, respectively, P = 0·012; P for gene-diet interaction = 0·004). There was no interaction effect between the 13041A>G polymorphism and diet-induced changes on the outcome variables (all P>0·1). These results confirm and extend previous findings suggesting that the PLIN1 11482G>A polymorphism plays a modulating role on diet-induced changes in body fat and energy metabolism in obese women.
本研究旨在探讨 PLIN1 11482G>A（rs894160）和 PLIN1 13041A>G（rs2304795）多态性与肥胖女性的身体成分、能量和底物代谢以及对 12 周能量限制饮食的代谢反应之间的关系。研究共纳入 78 名肥胖女性（BMI 34.0（SD 2.8）kg/m2）（年龄 36.7（SD 7）岁）。我们在 12 周的能量限制饮食干预前后测量了体重、身高和腰围。通过双能 X 射线吸收法测量体脂肪量和瘦体重。通过间接热量法测量静息代谢率和脂氧化率。我们还分析了空腹血糖、胰岛素、胆固醇和瘦素。携带 11482A 等位基因的女性腰围减少量低于非 A 等位基因携带者（分别为 3.2（SD 0.5）%和 4.6（SD 0.6）%，P=0.047；基因-饮食交互作用的 P 值=0.064）。此外，携带 11482A 等位基因的女性脂氧化率下降幅度高于非 A 等位基因携带者（分别为 58.9（SD 6.7）%和 31.3（SD 8.2）%，P=0.012；基因-饮食交互作用的 P 值=0.004）。13041A>G 多态性与饮食诱导的变化之间没有交互作用（所有 P 值均大于 0.1）。这些结果证实并扩展了先前的发现，表明 PLIN1 11482G>A 多态性在肥胖女性的体脂肪和能量代谢的饮食诱导变化中起调节作用。
