Labayen Idoia, Margareto Javier, Maldonado-Martin Sara, Gorostegi Ilargi, Illera Maitane, Medrano María, Barrenechea Lurdes, Larrarte Eider
Department of Nutrition and Food Science, University of the Basque Country, UPV/EHU, Vitoria, Spain. Elikadura, Ariketa fisikoa eta Osasuna, ELIKOS, Nutrition, Exercise and Health, Research group, University of the Basque Country, UPV/EHU, Vitoria, Spain..
Elikadura, Ariketa fisikoa eta Osasuna, ELIKOS, Nutrition, Exercise and Health, Research group, University of the Basque Country, UPV/EHU, Vitoria, Spain. Biomedical Research Area, TECNALIA, Miñano, Spain..
Nutr Hosp. 2015 May 1;31(5):2025-32. doi: 10.3305/nh.2015.31.5.8666.
To examine the independent and combined influence of the FTOrs9939609 and the MC4Rrs17782313 polymorphisms on changes in fat mass (FM), resting energy expenditure (REE), leptin, and thyrotropin (TSH) levels, after a 12-week energy-restricted diet intervention in non-morbid premenopausal obese women.
Fat mass (dual X-ray absorptiometry), REE (indirect calorimetry) and plasma leptin and thyrotropin levels were measured (before and after the intervention) in 77 obese (BMI: 33.9 ± 2.8 kg/m(2)) women (age: 36.8 ± 7.0y).
There were no significant differences across FTOrs9939609 genotype groups (TT vs. A allele carriers, Ps>0.1) on changes in body mass (-8.6 ± 3.2% vs. -8.7 ± 3.3 %), FM (12.8 ± 4.7% vs. -12.9 ± 6.3%), REE (-11.3 ± 4.7 vs. -9.4 ± 8.1%), leptin (-34.1 ± 25.1% vs. -43.5 ± 24.1%) or TSH (5.2 ± 34.5% vs. -1.7 ± 27.1%) levels. Moreover, it was not observed any significant difference on changes in body mass (-8.6 ± 3.6% vs. -8.9 ± 2.6%), FM (-12.7 ± 6.1% vs. -13.4 ± 5.3%), REE (-9.8 ± 7.4% -9.4 ± 9.4%), leptin (-39.0 ± 26.9% vs. -44.8 ± 18.4%) or TSH (-1.0 ± 30.0% vs. 1.5 ± 26.5%) levels between non-C allele carriers and C allele carriers of the MC4Rrs17782313 (Ps>0.3). Finally, there were no significant difference on changes in body mass and composition, REE, leptin or TSH levels among non-risk allele carriers, carriers of the C allele risk of the MC4Rrs17782313, carriers of the A allele of the FTOrs9939609 and carriers of both risk alleles after the 12-week energy-restricted diet intervention (Ps>0.1).
Carrying the A risk allele of the FTOrs9939609 and/or the C risk allele of the MC4Rrs17782313 did not influence body mass and FM loss, or REE decrease in obese women after a 12-week energy-restricted diet intervention.
研究在非病态绝经前肥胖女性中，进行为期12周的能量限制饮食干预后，FTO rs9939609和MC4R rs17782313基因多态性对脂肪量（FM）、静息能量消耗（REE）、瘦素和促甲状腺激素（TSH）水平变化的独立及联合影响。
对77名肥胖（BMI：33.9±2.8kg/m²）女性（年龄：36.8±7.0岁）在干预前后测量脂肪量（双能X线吸收法）、REE（间接测热法）以及血浆瘦素和促甲状腺激素水平。
FTO rs9939609基因型组（TT与A等位基因携带者）在体重变化（-8.6±3.2%对-8.7±3.3%）、FM（-12.8±4.7%对-12.9±6.3%）、REE（-1-1.3±4.7对-9.4±8.1%）、瘦素（-34.1±25.1%对-43.5±24.1%）或TSH（5.2±34.5%对-1.7±27.1%）水平上无显著差异。此外，在MC4R rs17782313的非C等位基因携带者与C等位基因携带者之间，体重变化（-8.6±3.6%对-8.9±2.6%）、FM（-12.7±6.±6.1%对-13.4±5.3%）、REE（-9.8±7.4%对-9.4±9.4%）、瘦素（-39.0±26.9%对-44.8±18.4%）或TSH（-1.0±30.0%对1.5±26.5%）水平也未观察到显著差异（P>0.3）。最后，在为期12周的能量限制饮食干预后，非风险等位基因携带者、MC4R rs17782313的C等位基因风险携带者、FTO rs9939609的A等位基因携带者以及两种风险等位基因携带者在体重和身体成分变化、REE、瘦素或TSH水平上均无显著差异（P>0.1）。
携带FTO rs9939609的A风险等位基因和/或MC4R rs17782313的C风险等位基因，对肥胖女性在为期12周的能量限制饮食干预后的体重和FM减少以及REE降低没有影响。
