Division of Developmental Stomatognathic Function Science, Department of Growth and Development of Functions, Kyushu Dental College, Kitakyushu, Japan.
Am J Orthod Dentofacial Orthop. 2011 Mar;139(3):e267-77. doi: 10.1016/j.ajodo.2009.05.028.
This study was performed to estimate the effects of risedronate on mandibular bone density, bone structure, and bone metabolism in established glucocorticoid-induced osteoporosis in growing rats.
The rats were given oral risedronate at 0, 0.5, or 1.0 mg per kilogram per day for 4 weeks after the administration of oral prednisolone at 30 mg per kilogram per 2 days for 6 weeks. Trabecular and cortical bone masses were analyzed by using peripheral quantitative computed tomography, and bone structure and bone formation were measured by using static and dynamic histomorphometry.
In trabecular bone, risedronate improved the prednisolone-induced decreases in bone cross-sectional area and bone mineral content. Risedronate increased bone density and also formed dense bone microarchitecture by reducing the bone turnover rate. In cortical bone, risedronate improved the prednisolone-induced decreases in bone cross-sectional area and bone mineral content without affecting bone density by increasing the mineralizing surface.
Risedronate improved prednisolone-induced retardation of trabecular and cortical bone growth, but the bone turnover in these 2 sites was regulated differently in the growing rat mandibles.
本研究旨在评估利塞膦酸钠对已建立的糖皮质激素诱导生长大鼠骨质疏松症下颌骨骨密度、骨结构和骨代谢的影响。
大鼠在给予 30mg/kg/2 天的口服泼尼松龙 6 周后，每天给予 0、0.5 或 1.0mg/kg 的利塞膦酸钠口服 4 周。通过外周定量计算机断层扫描分析小梁骨和皮质骨的骨量，通过静态和动态组织形态计量学测量骨结构和骨形成。
在小梁骨中，利塞膦酸钠改善了泼尼松龙引起的骨横截面积和骨矿物质含量减少。利塞膦酸钠通过降低骨转换率增加了骨密度，并形成了致密的骨微结构。在皮质骨中，利塞膦酸钠增加了矿化表面，改善了泼尼松龙引起的骨横截面积和骨矿物质含量减少，而不影响骨密度。
利塞膦酸钠改善了泼尼松龙诱导的生长大鼠下颌骨小梁和皮质骨生长的延迟，但这两个部位的骨转换率受到不同的调节。
