Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei, PR China.
Eur J Med Chem. 2011 May;46(5):1914-8. doi: 10.1016/j.ejmech.2011.02.031. Epub 2011 Feb 22.
Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5-dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.
合成了 8 种新的 5-芳基-3-(吡啶-2-基)-4,5-二氢吡唑-1-甲硫酰胺的金(III)配合物（1-8），并通过元素分析、摩尔电导率、IR、UV、1H NMR、13C NMR、MS 和热分析技术进行了表征。通过 MTT 测定法测试了细胞毒性。结果表明，配合物 1-8 对 HeLa 和 A549 细胞系表现出细胞毒性作用。此外，配合物 1、4、5、7 和 8 对 HeLa 细胞系的细胞毒性高于顺铂。这表明苯环上的取代基对细胞毒性有重要影响。
