Department of Polymer Science and Engineering, Pusan National University, San 30, Jangjun Dong, Geumjeong-gu, Busan 609-735, Republic of Korea.
Colloids Surf B Biointerfaces. 2011 Jun 1;84(2):579-84. doi: 10.1016/j.colsurfb.2011.02.022. Epub 2011 Feb 21.
In this study, we focused on the adsorption of nicotine from aqueous solution such as water and simulated body fluids (SBFs), where SBF has ion concentrations approximately equal to those of human blood plasma. We prepared periodic mesoporous organosilica (PMO) materials as adsorbents from 4,4-bis(triethoxysilyl)biphenyl (BTES-biphenyl), 1,4-bis(triethoxysilyl)benzene (BTES-benzene) and bis[3-(trimethoxy silyl)propyl]amine (BTMS-amine) as precursors and investigated on their adsorption behavior of nicotine as a guest material under different solvent conditions. For this work, two different kinds of SBF, c-SBF and r-SBF, have been chosen, where c-SBF is a transitional SBF solution, and r-SBF is a modified SBF solution that is closer to human blood plasma. Adsorption of nicotine on PMOs has been characterized by a UV-Vis spectroscopy. The adsorption behavior was strongly dependent on the isoelectric point and hydrophobicity of the PMO as well as the hydrophobicity of nicotine.
在这项研究中，我们专注于从水溶液（如水和模拟体液（SBF））中吸附尼古丁，其中 SBF 的离子浓度与人体血浆的离子浓度大致相等。我们使用 4,4-双（三乙氧基硅基）联苯（BTES-联苯）、1,4-双（三乙氧基硅基）苯（BTES-苯）和双[3-（三甲氧基硅基）丙基]胺（BTMS-胺）作为前体，制备了周期性介孔有机硅（PMO）材料作为吸附剂，并研究了它们在不同溶剂条件下作为客体材料对尼古丁的吸附行为。为此，我们选择了两种不同的 SBF，即 c-SBF 和 r-SBF，其中 c-SBF 是一种过渡性 SBF 溶液，而 r-SBF 是一种更接近人体血浆的改良 SBF 溶液。通过紫外-可见光谱对尼古丁在 PMO 上的吸附进行了表征。吸附行为强烈依赖于 PMO 的等电点和疏水性以及尼古丁的疏水性。
