ICMR UMR 6229, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France.
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2510-4. doi: 10.1016/j.bmcl.2011.02.044. Epub 2011 Feb 17.
Our goal in the search for potentially bioactive analogues of KRN 7000 was to design an easy synthetic approach to a library of analogues using a strategy recently developed in our laboratory based on a Nucleophilic addition followed by an Epoxide Opening (the NEO strategy). Through the use of a common pivotal structure, a new C-galactoside ester analogue (23) was synthesized which showed an encouraging T(H)2 biased response during preliminary biological tests.
我们在寻找 KRN 7000 的潜在生物活性类似物的过程中，旨在设计一种简单的合成方法，通过最近在我们实验室中开发的基于亲核加成随后环氧化物开环（NEO 策略）的策略，来合成一系列类似物库。通过使用共同的关键结构，合成了一种新的 C-半乳糖苷酯类似物（23），在初步的生物学测试中显示出令人鼓舞的 T(H)2 偏向反应。
