Department of Breast Surgery, Affiliated Tumor Hospital of Harbin Medical University, 6 Baojian Road, Harbin 150040, China.
Breast. 2011 Aug;20(4):370-2. doi: 10.1016/j.breast.2011.02.011. Epub 2011 Mar 10.
The aim was to describe the clinicopathological features and prognosis of young patients with breast cancer.
We reviewed the records of 1478 consecutive patients aged ≤50 years with first diagnosis of invasive breast cancer referred to surgery from January 1999 to March 2005. A total of 174 patients were aged <35 years (group I) and 1304 were aged 35-50 years (group II).
Compared with patients of group II, patients of group I had a higher percentage of tumors classified as estrogen receptors (ER) negative, progesterone receptors (PR) negative, with a Ki-67 labeling index ≥20% of the cells. The 5-year survival of group I was 78.3% as compared with 84.2% for group II (P = 0.006).
Compared with patients aged between 35 and 50 years, patients aged <35 years have a greater chance of having an endocrine-unresponsive tumor and a significantly poor prognosis.
本研究旨在描述年轻乳腺癌患者的临床病理特征和预后。
我们回顾性分析了 1999 年 1 月至 2005 年 3 月期间因浸润性乳腺癌就诊于外科的 1478 例连续患者的记录。其中 174 例患者年龄<35 岁（组 I），1304 例患者年龄为 35-50 岁（组 II）。
与组 II 相比，组 I 的肿瘤 ER 阴性、PR 阴性、Ki-67 细胞标记指数≥20%的比例更高。组 I 的 5 年生存率为 78.3%，而组 II 的 5 年生存率为 84.2%（P=0.006）。
与 35-50 岁的患者相比，年龄<35 岁的患者更有可能存在内分泌反应性肿瘤，且预后明显较差。
