年轻乳腺癌患者的临床病理特征和预后。
Clinicopathologic characteristics and prognosis of young patients with breast cancer.
机构信息
Department of Breast Surgery, Affiliated Tumor Hospital of Harbin Medical University, 6 Baojian Road, Harbin 150040, China.
出版信息
Breast. 2011 Aug;20(4):370-2. doi: 10.1016/j.breast.2011.02.011. Epub 2011 Mar 10.
BACKGROUND
The aim was to describe the clinicopathological features and prognosis of young patients with breast cancer.
PATIENTS AND METHODS
We reviewed the records of 1478 consecutive patients aged ≤50 years with first diagnosis of invasive breast cancer referred to surgery from January 1999 to March 2005. A total of 174 patients were aged <35 years (group I) and 1304 were aged 35-50 years (group II).
RESULTS
Compared with patients of group II, patients of group I had a higher percentage of tumors classified as estrogen receptors (ER) negative, progesterone receptors (PR) negative, with a Ki-67 labeling index ≥20% of the cells. The 5-year survival of group I was 78.3% as compared with 84.2% for group II (P = 0.006).
CONCLUSION
Compared with patients aged between 35 and 50 years, patients aged <35 years have a greater chance of having an endocrine-unresponsive tumor and a significantly poor prognosis.
背景
本研究旨在描述年轻乳腺癌患者的临床病理特征和预后。
患者和方法
我们回顾性分析了 1999 年 1 月至 2005 年 3 月期间因浸润性乳腺癌就诊于外科的 1478 例连续患者的记录。其中 174 例患者年龄<35 岁（组 I），1304 例患者年龄为 35-50 岁（组 II）。
结果
与组 II 相比，组 I 的肿瘤 ER 阴性、PR 阴性、Ki-67 细胞标记指数≥20%的比例更高。组 I 的 5 年生存率为 78.3%，而组 II 的 5 年生存率为 84.2%（P=0.006）。
结论
与 35-50 岁的患者相比，年龄<35 岁的患者更有可能存在内分泌反应性肿瘤，且预后明显较差。
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