Department of Angiology, Vienna Medical University, Vienna, Austria.
Vasc Med. 2011 Apr;16(2):97-102. doi: 10.1177/1358863X11400780. Epub 2011 Mar 10.
Children's obesity is a growing problem in Western societies. We hypothesized that morbid obesity (body mass index [BMI] > 99.5th percentile) might affect microvascular function at an early stage. Therefore, we assessed the microvascular function of 41 obese children (13.2 ± 2.8 years, BMI 32.9 ± 6.6) in comparison to 91 healthy controls (12.7 ± 2.1 years, BMI 18.2 ± 2.5) by post-occlusive reactive hyperemia measured by a laser Doppler: baseline perfusion, biological zero (defined as 'no-flow' laser Doppler signal during supracystolic occlusion), peak perfusion (following occlusion), time to peak perfusion and recovery time (time until resuming baseline perfusion) were recorded and compared between both groups. Peak perfusion was higher in children with morbid obesity than in controls (1.67 ± 0.76 AU [arbitrary units] vs 1.26 ± 0.5 AU, p < 0.001). Consecutively, recovery time was longer in children with morbid obesity (118.21 ± 34.64 seconds) than in healthy children (83.18 ± 35.08 seconds, p < 0.001). In conclusion, higher peak perfusion and prolonged recovery time in children with morbid obesity seem to reflect microvascular dysfunction due to an impaired vasoconstrictive ability of precapillary sphincters.
儿童肥胖症是西方社会日益严重的问题。我们假设病态肥胖症（体重指数 [BMI] > 99.5 百分位）可能在早期影响微血管功能。因此，我们通过激光多普勒评估了 41 名肥胖儿童（13.2 ± 2.8 岁，BMI 32.9 ± 6.6）的微血管功能，与 91 名健康对照组（12.7 ± 2.1 岁，BMI 18.2 ± 2.5）进行了比较。通过闭塞后反应性充血来测量：记录并比较两组的基线灌注、生物学零（定义为在超射性闭塞期间“无流”激光多普勒信号）、峰值灌注（闭塞后）、达到峰值灌注的时间和恢复时间（恢复到基线灌注的时间）。病态肥胖儿童的峰值灌注高于对照组（1.67 ± 0.76 AU [任意单位] vs 1.26 ± 0.5 AU，p < 0.001）。接着，病态肥胖儿童的恢复时间（118.21 ± 34.64 秒）长于健康儿童（83.18 ± 35.08 秒，p < 0.001）。总之，病态肥胖儿童的峰值灌注升高和恢复时间延长似乎反映了微血管功能障碍，这是由于前毛细血管括约肌的血管收缩能力受损所致。
