Department of Pediatrics, School of Medicine, Yuzuncu Yil University, Van, Turkey.
Hum Exp Toxicol. 2011 Nov;30(11):1751-60. doi: 10.1177/0960327111401638. Epub 2011 Mar 10.
The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status.
The study includes 69 full-term newborns (neonates with hyperbilirubinemia needing phototherapy [Group 1, n = 36] and neonates with kernicterus [Group 2, n = 33]) and 25 age-matched healthy newborn.
Plasma total antioxidant capacity (TAC) and serum total oxidant status (TOS) were significantly higher in Groups 1 and 2 than the control group. There was a significant difference between Group 1 and control cases for malondialdehyde (MDA; p < 0.001). Total free sulfhydryl group (TTHI) values were significantly elevated in Group 1 compared to Group 2 and control cases. Correlation analysis showed that the correlation between total bilirubin (TB) and TAC, TOS, MDA and oxidative stress index may be expressed by a quadratic curve. After phototherapy, a statistically significant increase in nitrite level was observed.
We demonstrated that the relationship between serum TB and antioxidants and oxidative stress could be expressed by a quadratic correlation curve.
本研究旨在确定高胆红素血症和/或核黄疸婴儿的氧化应激和抗氧化状态，并探讨胆红素水平与氧化应激/抗氧化状态之间的关系。
本研究纳入了 69 例足月新生儿（需要光疗的高胆红素血症新生儿[第 1 组，n=36]和核黄疸新生儿[第 2 组，n=33]）和 25 名年龄匹配的健康新生儿。
第 1 组和第 2 组的血浆总抗氧化能力（TAC）和血清总氧化状态（TOS）均显著高于对照组。第 1 组的丙二醛（MDA）与对照组相比差异有统计学意义（p<0.001）。与第 2 组和对照组相比，第 1 组的总巯基（TTHI）值显著升高。相关性分析表明，总胆红素（TB）与 TAC、TOS、MDA 和氧化应激指数之间的相关性可用二次曲线表示。光疗后，亚硝酸盐水平显著升高。
我们证明了血清 TB 与抗氧化剂和氧化应激之间的关系可以用二次相关曲线来表示。
