Bhutoria Samar, Oneil Ciaran
Department of ENT, Altnagelvin Area Hospital, Londonderry, BT47 6SB, United Kingdom.
Indian J Pathol Microbiol. 2011 Jan-Mar;54(1):136-7. doi: 10.4103/0377-4929.77367.
Embryonal rhabdomyosarcoma is the most common soft tissue sarcoma in children. We report a rare case of embryonal rhabdomyosarcoma of the soft palate in a 32-year-old Caucasian female. Detailed histology of the tumor is described. Positive staining with desmin, myogenin and myoD1 confirmed the tumor to be embryonal rhabdomyosarcoma. A genetic association between rhabdomyosarcoma, polycystic ovary syndrome and the FEM1A gene on the human chromosome is speculated upon.
胚胎性横纹肌肉瘤是儿童最常见的软组织肉瘤。我们报告一例罕见的32岁高加索女性软腭胚胎性横纹肌肉瘤病例。描述了肿瘤的详细组织学情况。结蛋白、肌细胞生成素和肌分化抗原1（MyoD1）的阳性染色证实该肿瘤为胚胎性横纹肌肉瘤。推测横纹肌肉瘤、多囊卵巢综合征与人类染色体上的FEM1A基因之间存在遗传关联。
