Masilamani Suresh, Rao Shalinee, Chirakkal Pramod, Kumar A Ravi
Department of Pathology, Sri Ramachandra University, Porur, Chennai 600116, India.
Indian J Pathol Microbiol. 2011 Jan-Mar;54(1):167-9. doi: 10.4103/0377-4929.77393.
Hyalinizing clear cell carcinoma (HCCC) of tongue is a rare neoplasm originating from minor salivary glands. We present a case of HCCC involving the base of tongue, in a 73-year-old male, clinically diagnosed as fibroma. Laser excision of the mass was done. Histopathological examination showed an infiltrating lesion composed predominantly of clear cells. The differential diagnosis included other salivary gland lesions having a clear cell component and metastatic clear cell renal carcinoma. Immunohistochemistry was useful in ruling out these lesions exhibiting clear cell component from clear cell carcinoma. Imaging studies revealed no lesion in either kidney. Since, HCCC has a better prognosis and the adequate treatment is wide excision, it needs to be differentiated from other carcinomas with clear cells. No further therapy was given to the patient. One year after the surgery, the patient is symptom free without local recurrence and on regular follow up.
舌部透明细胞硬化性癌（HCCC）是一种起源于小唾液腺的罕见肿瘤。我们报告一例发生于舌根部的HCCC病例，患者为73岁男性，临床诊断为纤维瘤。对肿物进行了激光切除。组织病理学检查显示为主要由透明细胞组成的浸润性病变。鉴别诊断包括其他具有透明细胞成分的唾液腺病变和转移性透明细胞肾细胞癌。免疫组织化学有助于排除这些具有透明细胞成分的病变与透明细胞癌的混淆。影像学检查显示双侧肾脏均无病变。由于HCCC预后较好，充分的治疗方法是广泛切除，因此需要将其与其他具有透明细胞的癌进行鉴别。该患者未接受进一步治疗。术后一年，患者无症状，无局部复发，正在定期随访。
