Department of Pathology, Mustafa Kemal University, Faculty of Medicine, Hatay, Turkey.
Indian J Dermatol Venereol Leprol. 2011 Mar-Apr;77(2):251. doi: 10.4103/0378-6323.77483.
Basal cell carcinomas (BCCs) are the most prevalent cancer type among white-skinned populations worldwide.
To analyze the gender and age-related incidence of basal cell carcinoma (BCC) histopathologic subtypes, to classify BCCs according to their anatomical location, invasion depth, and size, and to determine the relationship between BCC subtypes and margin of surgical excision.
All BCCs analysed in our center between 2005 and 2010 were studied retrospectively. The samples, which were totally excised, were included on the basis of histopathological diagnosis of BCC, and confirmed by two pathologists. Patient data included sex, age at diagnosis, tumor location, histological subtypes, invasion depth, and size.
We recorded 197 BCCs obtained from 181 white patients (80 females, 101 males). The mean age among males was 64.11, and 59.33 among females. Of the cases, 45.17% were nodular, 22.33% were mixed, and 15.22 were infiltrative type. 91.84% of the cases were located on the head and neck, 3.04% were on the limbs, and 1.52 % were on the trunk. In 32 cases, the margin of surgical excision was positive (17.7%): nodular 12%, infiltrative 43.3%, mixed 20.6%, micronodular 10%, and superfacial multicentric 5.5%. Of these total 32 cases, 34.4% were located on the eyes region, 28.1% were found on the nose, and 15.6% were on the ears. Invasion depth of tumors varied from 0.5 to 22.125 mm.
The results of our study exhibit differences in anatomical distribution, sex and mean age, invasion depth, and size of BCC subtypes. The recurrence rate for incompletely excised tumors varies according to the location and type of the tumor. Infiltrative tumors are more likely to recur and have positive margin of surgical excision. The highest positive margin of surgical excision is in infiltrative BCC. Tumors at difficult-to-treat sites and large and/or deeply invasive tumors are more liable to recur.
基底细胞癌（BCC）是全世界白种人群中最常见的癌症类型。
分析基底细胞癌（BCC）组织病理学亚型与性别和年龄的相关性，根据解剖位置、浸润深度和大小对 BCC 进行分类，并确定 BCC 亚型与手术切除边缘的关系。
对 2005 年至 2010 年间在我们中心分析的所有 BCC 进行回顾性研究。根据 BCC 的组织病理学诊断和两位病理学家的确认，对完全切除的样本进行了研究。患者数据包括性别、诊断时的年龄、肿瘤位置、组织学亚型、浸润深度和大小。
我们记录了 181 名白人患者（80 名女性，101 名男性）中 197 例 BCC。男性的平均年龄为 64.11 岁，女性为 59.33 岁。病例中，45.17%为结节型，22.33%为混合型，15.22%为浸润型。91.84%的病例位于头颈部，3.04%位于四肢，1.52%位于躯干。32 例手术切除边缘阳性（17.7%）：结节型 12%，浸润型 43.3%，混合型 20.6%，微结节型 10%，浅表多中心型 5.5%。在这 32 例总病例中，34.4%位于眼部区域，28.1%位于鼻部，15.6%位于耳部。肿瘤的浸润深度从 0.5 至 22.125 毫米不等。
我们的研究结果显示 BCC 亚型在解剖分布、性别和平均年龄、浸润深度和大小方面存在差异。未完全切除肿瘤的复发率因肿瘤位置和类型而异。浸润性肿瘤更有可能复发，且手术切除边缘呈阳性。浸润性 BCC 的手术切除边缘阳性率最高。位于难以治疗部位、大而/或深浸润性肿瘤的患者更容易复发。
